Author:Mathekga, BSP; Nxumalo, Precious Z; Thimiri Govindaraj, Deepak BDate:Jan 2022In this book chapter, we elaborate on the state-of-the-art technology developments in high throughput screening, microfluidics and nanofluidics. This book chapter further elaborated on the application of microfluidics and nanofluidics for ...Read more
Author:Grobler, Lichelle R; Suleman, Essa; Thimiri Govindaraj, Deepak BDate:Feb 2021CRISPR technology has revolutionized biological research in the last decade and many academic institutions and companies have patented CRISPR systems and applications. Several patents have been filed for various applications of CRISPR in ...Read more
Author:Nxumalo, Precious Z; Takundwa, MM; Thimiri Govindaraj, Deepak BDate:Feb 2021In this review chapter, we provide full comprehensive analysis on the patent, ethics and biosafety regulation with respect to the application of CRISPR technology in mammalian systems. We focused on recent development in CRISPR technology and ...Read more
Author:Latha, S; Palanisamy, S; Chakrapani, P; Harinia, R; Babu, PS; Thimiri Govindaraj, Deepak BDate:Mar 2021Background: Drug delivery is a science that requires the development of tailored systems that can deliver defi nedquantities of a therapeutic payload at a specifi c target site, at a controlled release rate, with or without a specifi c ...Read more
Author:Batohi, Nikayla; Dreyer, G; Thimiri Govindaraj, Deepak BDate:Jan 2023More than half of the women diagnosed with ovarian cancer ultimately succumb to death after 5 years of diagnosis. Standard platinum-based chemotherapy often results in patient relapse; thus, new therapeutic strategies are required. We aim to ...Read more
Author:Latha, S; Selvamani, P; Suganya, G; Thimiri Govindaraj, Deepak B; Pal, TKDate:Jun 2021Magnetic microspheres incorporated with pantoprazole sodium—a proton pump inhibitor—were formulated by using two different polymers such as ethyl cellulose and Eudragit RS-100. The magnetic microspheres were prepared by emulsion solvent ...Read more
Author:Smith, Tanya; O’Kennedy, Martha M; Ross, CS; Lewis, NS; Abolnik, CDate:Feb 2023Newcastle disease (ND) is a highly contagious viral respiratory and neurological disease that has a severe impact on poultry production worldwide. In the present study, an expression platform was established for the transient production in ...Read more
Author:Baichan, P; Naicker, Previn; Augustine, TN; Smith, M; Candy, G; Devar, J; Nweke, EEDate:Mar 2023Background Gallbladder cancer (GBC) is a lethal cancer with a poor prognosis. The lack of specifc and sensitive biomarkers results in delayed diagnosis with most patients presenting at late stages of the disease. Furthermore, there is little ...Read more
Author:Koenig, C; Martinez-Val, A; Naicker, Previn; Stoychev, S; Jordaan, J; Olsen, JVDate:Sep 2023Tandem mass tags data-dependent acquisition (TMT-DDA) as well as data-independent acquisition-based label-free quantification (LFQ-DIA) have become the leading workflows to achieve deep proteome and phosphoproteome profiles. We present a ...Read more
Author:Kabwe, KP; Nsibande, SA; Lemmer, Yolandy; Pilcher, LA; Forbes, PBCDate:Nov 2021This work explores the potential use of cadmium-based quantum dots (QDs) coupled to mycolic acids (MAs) as a fluorescent probe to detect anti-MA antibodies which are biomarkers for tuberculosis (TB). The use of free MAs as antigens for the ...Read more
Author:Thimiri Govindaraj, Deepak BDate:Nov 2021Optimizing Drug discovery and Translation is one of the key tracks in Global Challenges Annual meeting 2019 and is the critical factor in achieving UN Sustainable Development Goals 3 Good Health and Well Being. WHO reports Cancer is the second ...Read more
Author:Malise, TTA; Nweke, EE; Takundwa, Mutsa M; Fru, PF; Thimiri Govindaraj, Deepak BDate:May 2023In the past few years, development of approved drug candidates has improved the disease management of multiple myeloma (MM). However, due to drug resistance, some of the patients do not respond positively, while some of the patients acquire ...Read more