Browsing Research Publications/Outputs by Author "Zeevaart, JG"

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An integrated chemo-enzymatic route for preparation of ß-thymidine, a key intermediate in the preparation of antiretrovirals

Author: Gordon, GER ; Bode, ML ; Visser, Daniel F ; Lepuru, MJ ; Zeevaart, JG ; Ragubeer, N ; Ratsaka, M ; Walwyn, DR ; Brady, D Date: Jan 2011 A chemo-enzymatic method for production of ß-thymidine, an intermediate in the synthesis of antiretrovirals, is described. Guanosine and thymine were converted by means of enzymatic transglycosylation to yield 5-methyluridine (5-MU), which ... Read more
Palladium-catalysed arylation of acetoacetate esters to yield 2-arylacetic acid esters

Author: Zeevaart, JG ; Parkinson, CJ ; De Koning, CB Date: 24 May 2004 The coupling reaction between ethyl acetoacetate and a number of aryl halides in the presence of palladium acetate, a bulky and electron rich phosphine and K3PO4 is described. The arylated acetoacetate ester is de-acylated under the reaction ... Read more
Palladium-catalysed arylation of sulfonamide stabilised enolates

Author: Zeevaart, JG ; Parkinson, CJ ; De Koning, CB Date: 07 Mar 2005 Alpha-Arylation of inethanesulfonamides using palladium catalysis is described. For example, treatment of N-benzyl-Nmethylmethanesulfonamide with catalytic Pd (OAc) (2) in the presence of sodium tert-butoxide, triphenylphosphine and toluene ... Read more

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Browsing Research Publications/Outputs by Author "Zeevaart, JG"

Browsing Research Publications/Outputs by Author "Zeevaart, JG"

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