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Please use this identifier to cite or link to this item: http://hdl.handle.net/10204/1502

Title: Palladium-catalysed arylation of acetoacetate esters to yield 2-arylacetic acid esters
Authors: Zeevaart, JG
Parkinson, CJ
De Koning, CB
Keywords: Palladium catalysis
Enolate arylation
Arylacetic acid esters
Organic chemistry
Issue Date: 24-May-2004
Publisher: Pergamon-Elsevier Science Ltd
Citation: Zeevaart, JG, Parkinson, CJ and De Koning, CB. 2004. Palladium-catalysed arylation of acetoacetate esters to yield 2-arylacetic acid esters. Tetrahedron Letters, vol. 45(22), pp 4261-4264
Abstract: The coupling reaction between ethyl acetoacetate and a number of aryl halides in the presence of palladium acetate, a bulky and electron rich phosphine and K3PO4 is described. The arylated acetoacetate ester is de-acylated under the reaction conditions resulting in the generation of 2-arylacetic acid esters, constituting a mild alternative to direct arylation of carboxylate esters.
URI: http://hdl.handle.net/10204/1502
http://hdl.handle.net/10204/1502
ISSN: 0040-4039
Appears in Collections:Yeast expression systems
General science, engineering & technology

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