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Synthesis of 2-substituted tetrahydroisoquinolin-6-ols: Potential scaffolds for estrogen receptor modulation and/or microtubule degradation

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dc.contributor.author Mabank, T
dc.contributor.author Alexandre, Kabamba B
dc.contributor.author Pelly, SC
dc.contributor.author Green, IR
dc.contributor.author Van Otterlo, WAL
dc.date.accessioned 2020-02-27T10:35:56Z
dc.date.available 2020-02-27T10:35:56Z
dc.date.issued 2019-07
dc.identifier.citation Mabank, T., Alexandre, K.B., Pelly, S.C., Green, I.R. and Van Otterlo, W.A.L. 2019. Synthesis of 2-substituted tetrahydroisoquinolin-6-ols: Potential scaffolds for estrogen receptor modulation and/or microtubule degradation. ARKIVOC, July 2019, Part 4, pp 245-279. en_US
dc.identifier.issn 1551-7012
dc.identifier.uri https://www.arkat-usa.org/get-file/67071/
dc.identifier.uri https://www.arkat-usa.org/arkivoc-journal/browse-arkivoc/ark.5550190.p010.962
dc.identifier.uri http://hdl.handle.net/10204/11303
dc.description Copyright: 2019 ARKAT USA INC. Content is disseminated under a Creative Commons Attribution License (CC BY) en_US
dc.description.abstract 6-Methoxytetrahydroisoquinoline hydrochloride was converted into four small libraries of substituted ureas, thioureas, sulfonamides and N-aryls, using the tetrahydroisoquinoline nitrogen as the scaffold-linking atom. Some of the compounds were evaluated for their ability to inhibit cell proliferation using the MCF7 (invasive ductal carcinoma) cell line. en_US
dc.language.iso en en_US
dc.publisher ARKAT USA INC en_US
dc.relation.ispartofseries Worklist;22668
dc.subject 6-Hydroxytetrahydroisoquinolines en_US
dc.subject Anti-cancer en_US
dc.subject Estrogen modulators en_US
dc.subject Sulfonamides en_US
dc.subject Thioureas en_US
dc.subject Ureas en_US
dc.title Synthesis of 2-substituted tetrahydroisoquinolin-6-ols: Potential scaffolds for estrogen receptor modulation and/or microtubule degradation en_US
dc.type Article en_US
dc.identifier.apacitation Mabank, T., Alexandre, K. B., Pelly, S., Green, I., & Van Otterlo, W. (2019). Synthesis of 2-substituted tetrahydroisoquinolin-6-ols: Potential scaffolds for estrogen receptor modulation and/or microtubule degradation. http://hdl.handle.net/10204/11303 en_ZA
dc.identifier.chicagocitation Mabank, T, Kabamba B Alexandre, SC Pelly, IR Green, and WAL Van Otterlo "Synthesis of 2-substituted tetrahydroisoquinolin-6-ols: Potential scaffolds for estrogen receptor modulation and/or microtubule degradation." (2019) http://hdl.handle.net/10204/11303 en_ZA
dc.identifier.vancouvercitation Mabank T, Alexandre KB, Pelly S, Green I, Van Otterlo W. Synthesis of 2-substituted tetrahydroisoquinolin-6-ols: Potential scaffolds for estrogen receptor modulation and/or microtubule degradation. 2019; http://hdl.handle.net/10204/11303. en_ZA
dc.identifier.ris TY - Article AU - Mabank, T AU - Alexandre, Kabamba B AU - Pelly, SC AU - Green, IR AU - Van Otterlo, WAL AB - 6-Methoxytetrahydroisoquinoline hydrochloride was converted into four small libraries of substituted ureas, thioureas, sulfonamides and N-aryls, using the tetrahydroisoquinoline nitrogen as the scaffold-linking atom. Some of the compounds were evaluated for their ability to inhibit cell proliferation using the MCF7 (invasive ductal carcinoma) cell line. DA - 2019-07 DB - ResearchSpace DP - CSIR KW - 6-Hydroxytetrahydroisoquinolines KW - Anti-cancer KW - Estrogen modulators KW - Sulfonamides KW - Thioureas KW - Ureas LK - https://researchspace.csir.co.za PY - 2019 SM - 1551-7012 T1 - Synthesis of 2-substituted tetrahydroisoquinolin-6-ols: Potential scaffolds for estrogen receptor modulation and/or microtubule degradation TI - Synthesis of 2-substituted tetrahydroisoquinolin-6-ols: Potential scaffolds for estrogen receptor modulation and/or microtubule degradation UR - http://hdl.handle.net/10204/11303 ER - en_ZA


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