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Synthesis, characterization and in vitro cytotoxicity evaluation of polyamidoamine conjugate containing pamidronate and platinum drug

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dc.contributor.author Ndamase, AS
dc.contributor.author Aderibigbe, BA
dc.contributor.author Sadiku, ER
dc.contributor.author Labuschagne, Philip W
dc.contributor.author Lemmer, Yolandy
dc.contributor.author Ray, Suprakas S
dc.contributor.author Nwamadi, M
dc.date.accessioned 2018-02-07T10:34:20Z
dc.date.available 2018-02-07T10:34:20Z
dc.date.issued 2018-02
dc.identifier.citation Ndamase, A.S. et al. 2018. Synthesis, characterization and in vitro cytotoxicity evaluation of polyamidoamine conjugate containing pamidronate and platinum drug. Journal of Drug Delivery Science and Technology, vol. 43: 267-273 en_US
dc.identifier.issn 1773-2247
dc.identifier.uri https://www.sciencedirect.com/science/article/pii/S1773224717304197
dc.identifier.uri https://doi.org/10.1016/j.jddst.2017.10.011
dc.identifier.uri http://hdl.handle.net/10204/10024
dc.description Copyright: 2017 Elsevier. Due to copyright restrictions, the attached PDF file only contains the abstract of the full text item. For access to the full text item, please consult the publisher's website. en_US
dc.description.abstract Bisphosphonates have been found to be effective when combined with anticancer drugs for chemotherapy. In this paper, pamidronate and platinum complexes were conjugated to linear poly(amidoamine)s (PAMAM) to improve the drug efficacy. The conjugates were synthesized by aqueous phase Michael-addition polymerization reaction and characterized using SEM, TEM, XRD, FTIR, NMR and EDS to confirm successful conjugation of the drug to the polymeric carrier. In vitro cytotoxicity assays were performed against HeLa cell lines. FTIR, NMR and EDS confirmed the conjugation of the drugs to the polymer, and viability assay confirmed that the conjugates were not as toxic as the free drugs to the cells. The results obtained suggest that PAMAM are potential drug delivery devices for anticancer drugs with enhanced therapeutic effects. However, further characterization and in vitro tests will need to be conducted before further steps are taken. en_US
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries Worklist;20144
dc.subject Anticancer en_US
dc.subject Breast cancer en_US
dc.subject Combination therapy en_US
dc.subject Polyamidoamine en_US
dc.subject Polymer-drug conjugates en_US
dc.title Synthesis, characterization and in vitro cytotoxicity evaluation of polyamidoamine conjugate containing pamidronate and platinum drug en_US
dc.type Article en_US
dc.identifier.apacitation Ndamase, A., Aderibigbe, B., Sadiku, E., Labuschagne, P. W., Lemmer, Y., Ray, S. S., & Nwamadi, M. (2018). Synthesis, characterization and in vitro cytotoxicity evaluation of polyamidoamine conjugate containing pamidronate and platinum drug. http://hdl.handle.net/10204/10024 en_ZA
dc.identifier.chicagocitation Ndamase, AS, BA Aderibigbe, ER Sadiku, Philip W Labuschagne, Yolandy Lemmer, Suprakas S Ray, and M Nwamadi "Synthesis, characterization and in vitro cytotoxicity evaluation of polyamidoamine conjugate containing pamidronate and platinum drug." (2018) http://hdl.handle.net/10204/10024 en_ZA
dc.identifier.vancouvercitation Ndamase A, Aderibigbe B, Sadiku E, Labuschagne PW, Lemmer Y, Ray SS, et al. Synthesis, characterization and in vitro cytotoxicity evaluation of polyamidoamine conjugate containing pamidronate and platinum drug. 2018; http://hdl.handle.net/10204/10024. en_ZA
dc.identifier.ris TY - Article AU - Ndamase, AS AU - Aderibigbe, BA AU - Sadiku, ER AU - Labuschagne, Philip W AU - Lemmer, Yolandy AU - Ray, Suprakas S AU - Nwamadi, M AB - Bisphosphonates have been found to be effective when combined with anticancer drugs for chemotherapy. In this paper, pamidronate and platinum complexes were conjugated to linear poly(amidoamine)s (PAMAM) to improve the drug efficacy. The conjugates were synthesized by aqueous phase Michael-addition polymerization reaction and characterized using SEM, TEM, XRD, FTIR, NMR and EDS to confirm successful conjugation of the drug to the polymeric carrier. In vitro cytotoxicity assays were performed against HeLa cell lines. FTIR, NMR and EDS confirmed the conjugation of the drugs to the polymer, and viability assay confirmed that the conjugates were not as toxic as the free drugs to the cells. The results obtained suggest that PAMAM are potential drug delivery devices for anticancer drugs with enhanced therapeutic effects. However, further characterization and in vitro tests will need to be conducted before further steps are taken. DA - 2018-02 DB - ResearchSpace DP - CSIR KW - Anticancer KW - Breast cancer KW - Combination therapy KW - Polyamidoamine KW - Polymer-drug conjugates LK - https://researchspace.csir.co.za PY - 2018 SM - 1773-2247 T1 - Synthesis, characterization and in vitro cytotoxicity evaluation of polyamidoamine conjugate containing pamidronate and platinum drug TI - Synthesis, characterization and in vitro cytotoxicity evaluation of polyamidoamine conjugate containing pamidronate and platinum drug UR - http://hdl.handle.net/10204/10024 ER - en_ZA


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