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Browsing by Author "Hii, KK"

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Assessing a sustainable manufacturing route to lapatinib

Author: Stark, RT ; Rye, DR ; Newton, OJ ; Deadman, BJ ; Miller, PW ; Panayides, Jenny-Lee ; Riley, Darren L ; Helldardt, K ; Hii, KK Date: Aug 2022 A synthetic route to an anti-cancer drug, lapatinib, was devised to support the development of a sustainable manufacturing process in South Africa. Quantitative metrics were employed to evaluate the sustainability of the key steps of the reaction. Read more
Rapid formation of 2-lithio-1-(triphenylmethyl)imidazole and substitution reactions in flow†

Author: Wang, S ; Panayides, Jenny-Lee ; Riley, D ; Tighe, CJ ; Hii, KK Date: Sep 2021 The functionalisation of imidazoles is a necessary step in the formation of many active pharmaceutical intermediates. Herein, we report a flow chemistry approach for the rapid and efficient formation of 2-lithio-1-(triphenylmethyl)imidazole ... Read more

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Browsing by Author "Hii, KK"

Browsing by Author "Hii, KK"

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