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Browsing by Subject "Drug discovery"

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Inhibition of Plasmodium falciparum spermidine synthase indicates unique perturbation-specific effects in the transcriptome and proteome

Author: Becker, J ; Mtwisha, L ; Crampton, BG ; Stoychev, Stoyan H ; Van Brummelen, A ; Louw, A ; Birkholtz, L ; Mancama, Dalubuhle T Date: Mar 2009 Antiplasmodial drug discovery efforts are hampered by the lack of an extensive set of novel, validated drug targets. A requirement of these targets (or the pathways in which they function) is that they prove essential for parasite survival. ... Read more
Riminophenazine derivatives as potential antituberculosis agents: Synthesis, biological, and electrochemical evaluations

Author: Bvumbi, Mpelegeng V ; Van der Westhuyzen, Christiaan W ; Mmutlane, EM ; Ngwane, A Date: Jul 2021 A series of novel riminophenazine derivatives, having ionizable alkyl substituents at N-5 and a variety of substituents on the C-3 imino nitrogen, at C-8 and on the pendant aryl group, have been designed and synthesized. Preliminary investigations ... Read more
Riminophenazine derivatives as potential antituberculosis agents: Synthesis, biological, and electrochemical evaluations

Author: Bvumbi, Mpelegeng V ; Van der Westhuyzen, Christiaan W ; Mmutlane, EM ; Ngwane, A Date: Jul 2021 A series of novel riminophenazine derivatives, having ionizable alkyl substituents at N-5 and a variety of substituents on the C-3 imino nitrogen, at C-8 and on the pendant aryl group, have been designed and synthesized. Preliminary investigations ... Read more
Synthetic biology meets precision medicine: Drug repurposing for bloodcancer precision medicine

Author: Thimiri Govindaraj, Deepak B Date: Nov 2021 Optimizing Drug discovery and Translation is one of the key tracks in Global Challenges Annual meeting 2019 and is the critical factor in achieving UN Sustainable Development Goals 3 Good Health and Well Being. WHO reports Cancer is the second ... Read more
Systems biology tools to understand the role of host miRNAs in infection: a closer look at HIV

Author: Naidoo, Jerolen ; Brackin, R ; Khutlang, Rethabile ; Savulescu, A ; Mhlanga, Musa Date: Jun 2014 The discovery of mammalian microRNAs (miRNAs) has greatly enhanced our appreciation for the complexity associated with the regulation of the mammalian transcriptional landscape. Endogenous miRNA pathways mediate the targeted and subtle ... Read more
UCT943, a next-generation plasmodium falciparum PI4K inhibitor preclinical candidate for the treatment of Malaria

Author: Brunschwig, C ; Lawrence, N ; Taylor, D ; Abay, E ; Njoroge, M ; Basarab, GS ; Le Manach, C ; Paquet, T ; Cabrera, DG ; Mancama, Dalubuhle T Date: Sep 2018 The 2-aminopyridine MMV048 was the first drug candidate inhibiting Plasmodium phosphatidylinositol 4-kinase (PI4K), a novel drug target for malaria, to enter clinical development. In an effort to identify the next generation of PI4K inhibitors, ... Read more

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Browsing by Subject "Drug discovery"

Browsing by Subject "Drug discovery"

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