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Please use this identifier to cite or link to this item: http://hdl.handle.net/10204/4468

Title: Inhibition of Plasmodium falciparum spermidine synthase indicates unique perturbation-specific effects in the transcriptome and proteome
Authors: Becker, J
Mtwisha, L
Crampton, BG
Stoychev, S
Van Brummelen, A
Louw, A
Birkholtz, L
Mancama, D
Keywords: Plasmodium falciparum
Antimalarials
Drug targets
Drug discovery
Protozoan parasites
Issue Date: Mar-2009
Citation: Becker, J, Mtwisha, L, Crampton, BG. 2009. Inhibition of Plasmodium falciparum spermidine synthase indicates unique perturbation-specific effects in the transcriptome and proteome. Drug Discovery for Protozoan Parasites Conference. Beaver Run, Colorado, USA, 22 - 26 March 2009, pp1
Series/Report no.: POSTER
Abstract: Antiplasmodial drug discovery efforts are hampered by the lack of an extensive set of novel, validated drug targets. A requirement of these targets (or the pathways in which they function) is that they prove essential for parasite survival. The polyamine biosynthetic pathway, responsible for the metabolism of highly abundant amines crucial for parasite growth, proliferation and differentiation, is currently under investigation as an antimalarial target. In order to further evaluate polyamine depletion as possible antimalarial intervention, the consequences of inhibiting Plasmodium falciparum spermidine synthase was examined on a transcriptomic and proteomic level.
Description: Drug Discovery for Protozoan Parasites Conference. Beaver Run, Colorado, USA, 22 - 26 March 2009
URI: http://hdl.handle.net/10204/4468
Appears in Collections:Systems biology
General science, engineering & technology

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