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Combined atomistic molecular calculations and experimental investigations for the architecture, screening, optimization, and characterization of pyrazinamide containing oral film formulations for tuberculosis management

Author: Adeleke, Oluwatoyin A ; Monama, Nkwe O ; Tsai, PC ; Sithole, Happy M ; Michniak-Kohn, BB Date: Dec 2015 To date, effective treatment, prophylaxis, and control of tuberculosis (TB) infection is mainly dependent on the use of drugs. However, patient noncompliance with prescribed anti-TB treatment schemes remains a major problem confronting ... Read more
Preparation, characterization and ex vivo evaluation of an orally disintegrating film formulation containing pyrazinamide

Author: Adeleke, Oluwatoyin A ; Tsai, P-C ; Michniak-Kohn, BB Date: Oct 2015 The purpose of this research is to prepare, characterize as well as assess the ex vivo buccal drug delivery and cytotoxicity of an orally disintegrating film (ODF) loaded with pyrazinamide. Pyrazinamide (solubility = 15 mg/mL at 25°C; log P ... Read more

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Browsing by Subject "Pyrazinamide"

Browsing by Subject "Pyrazinamide"

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