The purpose of this research is to prepare, characterize as well as assess the ex vivo buccal drug delivery and cytotoxicity of an orally disintegrating film (ODF) loaded with pyrazinamide. Pyrazinamide (solubility = 15 mg/mL at 25°C; log P = -1.884) is an antimicrobial agent indicated for the treatment of tuberculosis (TB) especially in HIV-infected persons with TB co-infection as well as for multidrug and extensively drug resistant TB.
Reference:
Adeleke, O.A., Tsai, P-C, and Michniak-Kohn, BB. 2015. Preparation, characterization and ex vivo evaluation of an orally disintegrating film formulation containing pyrazinamide. In: American Association of Pharmaceutical Scientists Annual Meeting and Exposition, Orlando, United States of America, October 25-29, 2015
Adeleke, O. A., Tsai, P., & Michniak-Kohn, B. (2015). Preparation, characterization and ex vivo evaluation of an orally disintegrating film formulation containing pyrazinamide. http://hdl.handle.net/10204/9766
Adeleke, Oluwatoyin A, P-C Tsai, and BB Michniak-Kohn. "Preparation, characterization and ex vivo evaluation of an orally disintegrating film formulation containing pyrazinamide." (2015): http://hdl.handle.net/10204/9766
Adeleke OA, Tsai P, Michniak-Kohn B, Preparation, characterization and ex vivo evaluation of an orally disintegrating film formulation containing pyrazinamide; 2015. http://hdl.handle.net/10204/9766 .
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