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Browsing by Subject "Glutamine synthetase"

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3-substituted anilines as scaffolds for the construction of glutamine synthetase and DXP-reductoisomerase inhibitors

Author: Mutorwa, M ; Salisu, S ; Blatch, GL ; Kenyon, C ; Kaye, PT Date: Jan 2009 Access to a series of truncated ATP analogs, as potential anti-tuberculosis agents, has been explored via alkylation and acylation of 3-aminophenol, whereas chloroacetylation, using chloroacetyl chloride, and subsequent Arbuzov phosphonation ... Read more
Differential inhibition of adenylylated and deadenylylated forms of M. tuberculosis glutamine synthetase as a drug discovery platform

Author: Theron, Anjo ; Roth, Robyn L ; Hoppe, H ; Parkinson, C ; Van der Westhuyzen, Christiaan W ; Stoychev, Stoyan H ; Wiid, I ; Pietersen, RD ; Baker, B ; Kenyon, CP Date: Oct 2017 Glutamine synthetase is a ubiquitous central enzyme in nitrogen metabolism that is controlled by up to four regulatory mechanisms, including adenylylation of some or all of the twelve subunits by adenylyl transferase. It is considered a ... Read more
Studies towards the synthesis of ATP analogs as potential glutamine synthetase inhibitors

Author: Salisu, S ; Kenyon, C ; Kaye, PT Date: May 2011 In research directed at the development of adenine triphosphate (ATP) analogs as potential glutamine synthetase (GS) inhibitors, adenine and allopurinol derivatives have been synthesized either as novel ATP analogs or as scaffolds for the ... Read more

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Browsing by Subject "Glutamine synthetase"

Browsing by Subject "Glutamine synthetase"

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