ResearchSpace
→
Browsing by Subject

Browsing by Subject "Mycolic acids"

Now showing items 1-7 of 7

The antigenicity and cholesteroid nature of mycolic acids determined by recombinant chicken antibodies

Author: Ranchod, Heena ; Ndlandla, Fortunate L ; Lemmer, Yolandy ; Beukes, M ; Niebuhr, J ; Al-Dulayymi, J Date: Aug 2018 Mycolic acids (MA) are major, species-specific lipid components of Mycobacteria and related genera. In Mycobacterium tuberculosis, it is made up of alpha-, methoxy- and keto-MA, each with specific biological functions and conformational ... Read more
Cholesteroid nature of free mycolic acids from m. tuberculosis

Author: Benadie, Y ; Deysel, M ; Siko, DGR ; Roberts, VV ; Van Wyngaardt, S ; Thanyani, ST ; Sekanka, G ; Ten Bokum, AMC ; Collett, LA ; Grooten, J ; Baird, MS ; Verschoor, JA Date: 2008 Mycolic acids (MAs) are a major component of the cell walls of Mycobacterium tuberculosis and related organisms. These alpha-alkyl beta-hydroxy long fatty acids have been the subject of numerous studies for their immunological properties. The ... Read more
Mycolic acids, a promising mycobacterial ligand for targeting of nanoencapsulated drugs in tuberculosis

Author: Lemmer, Yolandy ; Kalombo, Lonji ; Pietersen, R-D ; Jones, AT ; Semete-Makokotlela, Boitumelo ; Van Wyngaardt, S ; Ramalapa, BE ; Stoltz, A ; Baker, B ; Verschoor, JA ; Swai, HS ; De Chastellier, C Date: Jun 2015 The appearance of drug-resistant strains of Mycobacterium tuberculosis (Mtb) poses a great challenge to the development of novel treatment programmes to combat tuberculosis. Since innovative nanotechnologies might alleviate the limitations ... Read more
Nanoencapsulation of Mycolic acids as a deliverable to macrophages

Author: Benadie, Y ; Semete, B ; Venter, L ; Kalombo, Lonji ; Driver, C ; Jones, AT ; Swai, H ; Verschoor, JA Date: Jun 2008 The cell wall envelope of Mycobacterium tuberculosis contains unique high molecular weight lipids. Of these, the most abundant are mycolic acids, an extended family of long 2-alkyl 3-hydroxyl fatty acids, typically 70-90 carbon atoms in length, ... Read more
Nanoencapsulation of mycolic acids as a deliverable to macrophages - 2nd CSIR Biennial Conference

Author: Benadie, Y ; Semete, B ; Venter, L ; Kalombo, Lonji ; Driver, C ; Jones, AT ; Swai, H ; Verschoor, JA Date: Nov 2008 The objective of this project was to explore the encapsulation of mycolic acids into vehicles other than liposomes for delivery into macrophages and addressing the challenges of low solubility. As vehicles nanoparticles (NP) have the advantage ... Read more
Synthesis and characterisation of quantum dots coupled to mycolic acids as a water-soluble fluorescent probe for potential lateral flow detection of antibodies and diagnosis of tuberculosis

Author: Kabwe, KP ; Nsibande, SA ; Lemmer, Yolandy ; Pilcher, LA ; Forbes, PBC Date: Nov 2021 This work explores the potential use of cadmium-based quantum dots (QDs) coupled to mycolic acids (MAs) as a fluorescent probe to detect anti-MA antibodies which are biomarkers for tuberculosis (TB). The use of free MAs as antigens for the ... Read more
Tuberculosis related drug-lipid interactions demonstrated by evanescent field biosensor

Author: Lemmer, Yolandy ; Siko, G ; Swai, H ; Verschoor, J Date: Aug 2009 This poster is the first demonstration of the use of the evanescent field biosensor to show the interaction between low molecular weight ligate/ligand pairs. The authors demonstrated the interaction of Amphotericin B to either immobilized ... Read more

Now showing items 1-7 of 7

Browse

All of ResearchSpace

Quick Links

Legislation and compliance

General Enquiries

Tel: + 27 12 841 2911
Email: callcentre@csir.co.za

Physical Address
Meiring Naudé Road
Brummeria
Pretoria
South Africa

Postal Address
PO Box 395
Pretoria 0001
South Africa

Social Connect

Resources on this site are free to download and reuse according to associated licensing provision. Please read the terms and conditions of usage of each resource.

Browsing by Subject "Mycolic acids"

Browsing by Subject "Mycolic acids"

Browse

All of ResearchSpace

Quick Links

Legislation and compliance

General Enquiries

Social Connect