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Browsing by Subject "Imidazo[1,2-a]pyridines"

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Compounds acting against HIV: Imidazo[1,2-a]pyridines as non-nucleoside reverse transcriptase inhibitors (NNRTIs)

Author: Bode, M ; Gledhill, Irvy MA ; Gravestock, D ; Hoppe, H ; Khan, T ; Moleele, S ; Nkabinde, L ; Pelly, S ; Van der Westhuyzen, Christiaan W Date: Sep 2010 A compound possessing anti-HIV activity similar to that of FDA-approved nevirapine was developed. It acts as a non-nucleoside reverse transcriptase inhibitor, the compound shows good cell permeability, and a quantitative structure activity ... Read more
Imidazo[1,2-a]pyridines as NNRTIs

Author: Bode, ML ; Gravestock, D ; Moleele, S ; Van der Westhuyzen, Christiaan W ; Hoppe, H ; Khan, T ; Pelly, SC Date: Jan 2010 The enzyme reverse transcriptase (RT) is a validated target for the development of anti-HIV drugs. Drugs acting against RT may act at either the catalytic site (NRTIs) or the allosteric site (NNRTIs). During random screening of a small in-house ... Read more
Multicomponent synthesis of imidazo [1,2-a] pyridines using catalytic zinc chloride

Author: Rousseau, AL ; Matlaba, P ; Parkinson, CJ Date: Jun 2007 The novel use of zinc chloride to catalyse the one-pot, three component synthesis of imidazo (1,2-a) pyridines for a range of substrates using either conventional heating or microwave radiation is described. This methodology afforded a number ... Read more

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Browsing by Subject "Imidazo[1,2-a]pyridines"

Browsing by Subject "Imidazo[1,2-a]pyridines"

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