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Browsing by Subject "Aptamer"

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Aptamer-Based Tumor-Targeted Diagnosis and Drug Delivery

Author: Woldekidan, Haregewoin B ; Woldesemayat, AA ; Adam, G ; Tafesse, Mesfin ; Thimiri Govindaraj, Deepak B Date: Jul 2022 Early cancer identification is crucial for providing patients with safe and timely therapy. Highly dependable and adaptive technologies will be required to detect the presence of biological markers for cancer at very low levels in the early ... Read more
Molecular interaction of gp120 and B40 aptamer: A potential new HIV-1 entry inhibitor drug

Author: Baron, MK ; Kinsley, N ; Sewell, BT ; Jaffer, MA ; Capovilla, A ; James, W ; Khati, M Date: Nov 2008 HIV-1 infection and its concomitant disease – Aids, remain major public health problems in southern Africa. While current antiretroviral drugs have prolonged the quality of life for many HIV-positive individuals, they do not eliminate the ... Read more
Selection of RNA aptamers against the M. tuberculosis EsxG protein using surface plasmon resonance-based SELEX

Author: Ngubane, NAC ; Gresh, L ; Pymb, A ; Rubin, EJ ; Khati, M Date: Jun 2014 Tuberculosis (TB), which is caused by Mycobacterium tuberculosis, remains one of the most prevalent infectious diseases worldwide which causes high morbidity and mortality. However, there is still limited understanding of the physiological ... Read more
UCLA1 aptamer inhibition of human immunodeficiency virus type 1 subtype C primary isolates in macrophages and selection of resistance

Author: Mufhandu, Hazel T ; Alexandre, Kabamba B ; Gray, ES ; Morris, L ; Khati, M Date: Sep 2016 We have previously shown that the aptamer, UCLA1, is able to inhibit HIV-1 replication in peripheral blood mononuclear cells (PBMCs) by binding to residues in gp120. In this study we examined whether UCLA1 was effective against HIV-1 subtype ... Read more

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Browsing by Subject "Aptamer"

Browsing by Subject "Aptamer"

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All of ResearchSpace

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