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Please use this identifier to cite or link to this item: http://hdl.handle.net/10204/2643

Title: Molecular interaction of gp120 and B40 aptamer: A potential new HIV-1 entry inhibitor drug
Authors: Baron, MK
Kinsley, N
Sewell, BT
Jaffer, MA
Capovilla, A
James, W
Khati, M
Keywords: Molecules
HIV
Aptamer
Drug
HIV/Aids epidemic
HIV-1 entry inhibitor drug
Issue Date: Nov-2008
Publisher: CSIR
Citation: Baron, MK, Kinsley, N, Sewell, BT et al. 2008. Molecular interaction of gp120 and B40 aptamer: A potential new HIV-1 entry inhibitor drug. Science real and relevant: 2nd CSIR Biennial Conference, CSIR International Convention Centre Pretoria, 17 & 18 November 2008, pp 1
Abstract: HIV-1 infection and its concomitant disease – Aids, remain major public health problems in southern Africa. While current antiretroviral drugs have prolonged the quality of life for many HIV-positive individuals, they do not eliminate the virus (2, 5). This is compounded by the rapid emergence of drug resistant HIV-1 strains. For these reasons, a search for novel antiretroviral agents with modalities different from those currently in use remains a high priority. As a novel strategy to combat the HIV/Aids epidemic, we have recently discovered and described small nucleic acid ligands called aptamers with antiviral activity (1, 4). These aptamers prevent HIV-1 infection by binding to gp120, which is the viral surface envelope glycoprotein necessary for the earliest stage of infection called entry. In this study we used in silico molecular modelling coupled with biochemical experiments to delineate the interaction of one of the aptamers called B40 and gp120; with a view of using the information to develop the aptamer as a novel HIV-1 entry inhibitor drug
Description: Science real and relevant: 2nd CSIR Biennial Conference, CSIR International Convention Centre Pretoria, 17 & 18 November 2008, pp 12
URI: http://hdl.handle.net/10204/2643
Appears in Collections:CSIR Conference 2008
General science, engineering & technology
Aptamer technology

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