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Browsing by Subject "Antimalarials"

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Inhibition of Plasmodium falciparum spermidine synthase indicates unique perturbation-specific effects in the transcriptome and proteome

Author: Becker, J ; Mtwisha, L ; Crampton, BG ; Stoychev, Stoyan H ; Van Brummelen, A ; Louw, A ; Birkholtz, L ; Mancama, Dalubuhle T Date: Mar 2009 Antiplasmodial drug discovery efforts are hampered by the lack of an extensive set of novel, validated drug targets. A requirement of these targets (or the pathways in which they function) is that they prove essential for parasite survival. ... Read more
Polymer-drug conjugates containing antimalarial drugs and antibiotics

Author: Alven, S ; Aderibigbe, BA ; Balogun, Mohammed O ; Matshe, William MR ; Ray, Suprakas S Date: Oct 2019 Most of the currently used antimalarial drugs suffer from drug resistance, poor bioavailability and biodegradability, drug toxicity and poor water solubility. To overcome some of the aforementioned limitations, combination therapy involving ... Read more
Synthesis, characterization and in vitro analysis of polymer-based conjugaes containing dihydrofolate reductase inhibitors

Author: Aderibigbe, AB ; Mhlatika, Z ; Nwamadi, M ; Balogun, Mohammed O ; Matshe, William MR Date: Feb 2019 Malaria is an acute disease that is caused by the protozoanPlasmodiumparasites. Drug resistance is the majorproblem that is hindering the control of this disease. In order to overcome drug resistance to commonly usedantimalarials, nanocarriers ... Read more
Synthesis, characterization and in vitro analysis of polymer-based conjugates containing dihydrofolate reductase inhibitors

Author: Aderibigbe, BA ; Mhlwatika, Z ; Nwamadi, M ; Balogun, Mohammed O ; Matshe, William MR Date: Apr 2019 Malaria is an acute disease that is caused by the protozoan Plasmodium parasites. Drug resistance is the major problem that is hindering the control of this disease. In order to overcome drug resistance to commonly used antimalarials, ... Read more

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Browsing by Subject "Antimalarials"

Browsing by Subject "Antimalarials"

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