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Browsing by Author "Naidoo, Dashnie"

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Accelerated approach of discovering plant derived drug leads for treatment of TB

Author: Naidoo, Dashnie ; Maharaj, VJ ; Moodley, N ; Sewnarain, P ; Ndlebe, VJ Date: Jun 2010 The research conducted by the Bioprospecting group to identify TB drug leads using the accelerated approach will be outlined. The Bioprospecting platform in collaboration with the South African National Botanical Institute (SANBI) has established ... Read more
Accelerated approach of discovering plant-derived drug leads for treatment of tuberculosis

Author: Naidoo, Dashnie ; Maharaj, V ; Steenkamp, P Date: 01 Sep 2010 The bioprospecting research group at CSIR biosciences undertakes research that taps into South Africa’s plant biodiversity with the aim of discovering natural products that can be used to develop new medicines effective against tuberculosis ... Read more
Anti-aging potential of extracts from Sclerocarya birrea (A. Rich.) Hochst and its chemical profiling by UPLC-Q-TOF-MS

Author: Shoko, T ; Maharaj, VJ ; Naidoo, Dashnie ; Tselanyane, Malefa L ; Nthambeleni, Rudzani ; Khorombi, Eric ; Apostolides, Z Date: Feb 2018 BACKGROUND: Degradation of components of the extracellular matrix such as elastin and collagen by elastase and collagenase accelerates skin aging. Phytochemicals that inhibit the activity of these enzymes can be developed as anti-aging ... Read more
Anti-aging potential of extracts from Sclerocarya birrea (A. Rich.) Hochst and its chemical profiling by UPLC-Q-TOF-MS

Author: Shoko, T ; Maharaj, VJ ; Naidoo, Dashnie ; Tselanyane, Malefa L ; Nthambeleni, Rudzani ; Khorombi, Eric ; Apostolides, Z Date: Feb 2018 BACKGROUND: Degradation of components of the extracellular matrix such as elastin and collagen by elastase and collagenase accelerates skin aging. Phytochemicals that inhibit the activity of these enzymes can be developed as anti-aging ... Read more
Antidiabetic, anti-oxidant and antimicrobial activities of Fadogia ancylantha extracts from Malawi

Author: Nyirenda, KK ; Saka, JDK ; Naidoo, Dashnie ; Maharaj, VJ ; Muller, CJF Date: Aug 2012 Ethnopharmacological relevance: Communities in Chilumba, Malawi use herbal tea prepared from Fadogia ancylantha Schweinf (Rubiaceae) leaves for the management of diabetes, hypertension and alleviation of symptoms of gastrointestinal disorders ... Read more
Antiprotozoal Isoflavan Quinones from Abrus precatorius ssp. africanus

Author: Hata, Y ; Raith, M ; Ebrahimi, SN ; Zimmermann, S ; Mokoka, T ; Naidoo, Dashnie ; Fouché, Gerda ; Maharaj, V ; Kaiser, M ; Brun, R ; Hamburger, M Date: Apr 2013 A library of 206 extracts from selected South African plants was screened in vitro against a panel of protozoan parasites, Plasmodium falciparum, Trypanosoma brucei rhodesiense, and Leishmania donovani. A CH(sub)2Cl(sub)2/MeOH (1:1) extract ... Read more
Antitrypanosomal isoflavan quinones from Abrus precatorius

Author: Hata, Y ; Ebrahimi, SN ; De Mieri, M ; Zimmermann, S ; Mokoka, T ; Naidoo, Dashnie ; Fouché, Gerda ; Maharaj ; Kaiser, M ; Brun, R ; Potterat, O ; Hamburger, M Date: Mar 2014 Human African trypanosomiasis is a neglected tropical disease in sub Saharan Africa that is fatal if left untreated. In a search for new natural products with antitrypanosomal activity, we recently identified abruquinones B and I from Abrus ... Read more
Discovering novel plant-derived drug leads for the treatment of HIV through an integrated approach

Author: Nthambeleni, R ; Moodley, N ; Maharaj, VJ ; Klimkait, T ; Matter, A ; Sewnarain, P ; Naidoo, Dashnie Date: 01 Sep 2010 HIV/AIDS is now the leading cause of death in Sub-Saharan Africa and has moved up to fourth place among all causes of death worldwide. According to estimates from the UNAIDS 2009 report (UNAIDS 2009) on the global AIDS epidemic, around 33.4 ... Read more
Flavonoids of Steganotaenia araliacea

Author: Omolo, JJ ; Maharaj, V ; Naidoo, Dashnie ; Malebo, HM ; Mtullu, S ; Lyaruu, HVM ; Koning, CB Date: 2014 Phytochemical investigation of the stem and bark of Steganotaenia araliacea led to the isolation of two flavonoids. The structures of these compounds were identified as apigenin 4'-glucoside 1 and sophoraflavone B 2 using spectroscopic analysis ... Read more
New herbal remedies from medicinal plants

Author: Naidoo, Dashnie Date: Nov 2006 The objectives of the conference were: Conservation of biological diversity Sustainable use of its components Fair and equitable sharing of the benefits arising out of the utilization of genetic resources Read more
New labdane-type diterpenoids from Leonotis leonurus support circumscription of Lamiaceae s.l.

Author: Naidoo, Dashnie ; Maharaj, V ; Crouch, NR ; Ngwane, A Date: Aug 2010 The genus Leonotis (Pers.) R.Br. comprises about 10 species, and has been placed within subfamily Lamioideae of the Lamiaceae. Genus members range in habit from tall herbs to small trees. All are native to tropical and/or southern Africa, ... Read more
A review of the experimental approaches used in clinical studies to evaluate the health benefits of plant food supplements associated with infectious diseases

Author: Naidoo, Dashnie ; Mancama, Dalubuhle T ; Meoni, P ; Maharaj, VJ ; Van Rooyen, S Date: 2015 The objective of this review was to evaluate the experimental approaches used in clinical trials to support the benefit claims of plant food supplements (PFS) with reported activity on infectious diseases. A literature search was conducted ... Read more
South African plants as a source of drugs to treat infectious diseases - TB, malaria and HIV.

Author: Pillay, P ; Naidoo, Dashnie ; Maharaj, VJ ; Moodley, N ; Sewnarain, P ; Van Rooyen, S ; Mthembu, X ; Khorombi, E Date: Nov 2008 CSIR Biosciences is actively involved in identifying new medicines effective against tuberculosis (TB), malaria and HIV based on South Africa’s rich biodiversity. As part of a national multidisciplinary consortium, the Bioprospecting research ... Read more

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Browsing by Author "Naidoo, Dashnie"

Browsing by Author "Naidoo, Dashnie"

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