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Please use this identifier to cite or link to this item: http://hdl.handle.net/10204/4300

Title: Accelerated approach of discovering plant-derived drug leads for treatment of tuberculosis
Authors: Naidoo, D
Maharaj, V
Steenkamp, P
Keywords: Plant-derived drug leads
Tuberculosis
Tuberculosis treatment
Bioprospecting
CSIR Conference 2010
Issue Date: 1-Sep-2010
Publisher: CSIR
Citation: Naidoo, D, Maharaj, V and Steenkamp, P. 2010. Accelerated approach of discovering plant-derived drug leads for treatment of tuberculosis. CSIR 3rd Biennial Conference 2010. Science Real and Relevant. CSIR International Convention Centre, Pretoria, South Africa, 30 August – 01 September 2010, pp 1
Abstract: The bioprospecting research group at CSIR biosciences undertakes research that taps into South Africa’s plant biodiversity with the aim of discovering natural products that can be used to develop new medicines effective against tuberculosis (TB). To achieve this, the group has implemented the accelerated 96 well plate fractionation approach (Figure 1) to speed up the identification of active ingredients and interesting chemical scaffolds for subsequent medicinal chemistry developments, and to prevent the repeated discovery of known and undesired compounds, thereby saving time and resources. To demonstrate the effectiveness of the accelerated approach, one of the organic plant extracts that displayed good anti-TB activity (MIC ≤ 250 μg/ml) was fractionated and screened for biological activity. The active fractions were analysed by UPLC-TO F-DADMS for UV, accurate mass and MS-MS fragmentation data to identify the compounds present. By using the data to search the Dictionary of natural products, scientists could identify the compound responsible for activity and could make upfront go/ no go decisions, depending on the compound’s desirability as a drug lead
Description: CSIR 3rd Biennial Conference 2010. Science Real and Relevant. CSIR International Convention Centre, Pretoria, South Africa, 30 August – 01 September 2010
URI: http://hdl.handle.net/10204/4300
Appears in Collections:CSIR Conference 2010
General science, engineering & technology

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