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Browsing by Author "Mthunzi-Kufa, Patience"

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Biocongugation of gold nanoparticles for surface plasmon resonance sensor

Author: Manoto, Sello L ; Malabi, Rudzani ; Ombinda-Lemboumba, Saturnin ; Mthunzi-Kufa, Patience Date: Mar 2019 Over the past few years gold nanoparticle (AuNPs) have become extremely interesting because they possess enhanced optical, electrical and chemical properties. AuNPs have the ability to form robust conjugates with biomolecules such as antibodies ... Read more
Biology at a single cell level

Author: Mthunzi-Kufa, Patience Date: Oct 2012 In this presentation the author highlights the use of lasers in micro-manipulating single cells and molecules. Read more
Biosensing multidrug-resistant TB genes using SPR

Author: Chauke, Sipho H ; Ombinda-Lemboumba, Saturnin ; Dube, FS ; Mthunzi-Kufa, Patience Date: Jan 2024 Tuberculosis (TB) is one of the most prevalent infectious diseases globally. Although it is curable, several factors, such as the inappropriate use of treatment drugs lead to drug-resistant strains of TB. The burden of infection is ... Read more
Characterisation of a Bessel beam optical cell sorting system using microspheres

Author: Lugongolo, Masixole Y ; Ombinda-Lemboumba, Saturnin ; Manoto, Sello L ; Mthunzi-Kufa, Patience Date: Feb 2020 Accurate sorting of specific particles in a mixed population is a desirable capability in the field of biomedical sciences. This enables researchers to purify samples by selecting only the particles of interest. Optical sorting is achieved ... Read more
Chemical sensor nanotechnology in pharmaceutical drug research

Author: Thobakgale, Setumo L ; Ombinda-Lemboumba, Saturnin ; Mthunzi-Kufa, Patience Date: Aug 2022 The increase in demand for pharmaceutical treatments due to pandemic-related illnesses has created a need for improved quality control in drug manufacturing. Understanding the physical, biological, and chemical properties of APIs is an important ... Read more
The combination of low level laser therapy and efavirenz drastically reduces HIV infection in TZM-bl cells

Author: Lugongolo, Masixole Y ; Manoto, Sello L ; Ombinda-Lemboumba, Saturnin ; Maaza, M ; Mthunzi-Kufa, Patience Date: Jun 2020 Human immunodeficiency virus (HIV) infection remains a global health challenge despite the use of antiretroviral therapy, which has led to a significant decline in the mortality rates. Owing to the unavailability of an effective treatment to ... Read more
Could low level laser therapy and highly active antiretroviral therapy lead to complete eradication of HIV-1 in vitro?

Author: Lugongolo, Masixole Y ; Manoto, Sello L ; Ombinda-Lemboumba, Saturnin ; Maaza, M ; Mthunzi-Kufa, Patience Date: Jan 2017 Human immunodeficiency virus (HIV-1) infection remains a major health problem despite the use of highly active antiretroviral therapy (HAART), which has greatly reduced mortality rates. Due to the unavailability of an effective vaccine or a ... Read more
Design and FDTD simulation of photonic crystal based sensor for biosensing applications

Author: Manoto, Sello L ; Mabena, Chemist M ; Malabi, Rudzani ; Ombinda-Lemboumba, Saturnin ; Mthunzi-Kufa, Patience Date: Mar 2019 Photonic crystals (PhCs) is a unique and flexible class of optical devices that are able to manipulate the electromagnetic fields of light. PhCs is a subwavelength grating structure with a periodic arrangement of a high refractive index layer ... Read more
Detection and quantification of iodine in biological fluids using photonic-based systems: UV-Vis and Transmission spectroscopy

Author: Mcotshana, Zenande KS ; Thwala, Nomcebo L ; Ombinda-Lemboumba, Saturnin ; Ramokolo, Lesiba R ; Lugongolo, Masixole Y ; Van Steen, E ; Mthunzi-Kufa, Patience Date: Jan 2024 Iodine is a crucial trace element that occurs in minute amounts in nature and is necessary for the development of bones, thyroid function, and several metabolic processes. Iodine deficiency, also known as hypothyroidism, affects millions of ... Read more
Detection of biological analytes using surface plasmon resonance as a biosensing technique for possible development of a point of care diagnostic tool

Author: Malabi, Rudzani ; Manoto, Sello L ; Ombinda-Lemboumba, Saturnin ; Maaza, Malik ; Mthunzi-Kufa, Patience Date: Feb 2019 Surface Plasmon Resonance (SPR) is a very powerful optical sensing technique that detects bimolecular binding interactions and it has turned out to be a suitable platform for clinical analysis. In biological and chemical sensing applications, ... Read more
Detection of mycobacterium tuberculosis using gold nanoparticles conjugated to TB antibodies

Author: Maphanga, Charles P ; Manoto, Sello L ; Ombinda-Lemboumba, Saturnin ; Mthunzi-Kufa, Patience Date: Mar 2021 In recent years, conjugated nanoparticles have gained significant applications in diagnostics, particularly gold nanoparticles (AuNPs). When functionalized with antibodies, AuNPs can selectively interact with cells and biomolecules. The ... Read more
Detection of viral pathogens using optical photonic techniques with the aid of selenium nanoparticles

Author: Mcotshana, Zenande KS ; Thwala, Nomcebo L ; Ombinda-Lemboumba, Saturnin ; Ramokolo, Lesiba R ; Thobakgale, Setumo L ; Lugongolo, Masixole Y ; Van Steen, E ; Mthunzi-Kufa, Patience Date: Jan 2024 Viral infections such as HIV and SARS-CoV-2 have significantly increased morbidity in humans and resulted in a significant number of fatalities globally, hence early detection is crucial, particularly at a point-of-care (POC) setting to prevent ... Read more
Development of collinear transmission plasmonic biosensor for detection of HIV-1

Author: Ombinda-Lemboumba, Saturnin ; Manoto, Sello L ; Maphanga, Charles P ; Malabi, Rudzani ; Mthunzi-Kufa, Patience Date: Feb 2020 Surface Plasmon Resonance (SPR) which is widely used to study interactions between different types of biomolecules, has emerged as a technique of choice for rapid and quantitative analyses. However, there are still some challenges on the use ... Read more
The effect of low-level laser therapy on severe acute respiratory syndrome coronavirus-2 infected cells

Author: Mngwengwe, Luleka ; Lugongolo, Masixole Y ; Ombinda-Lemboumba, Saturnin ; Ismail, Y ; Mthunzi-Kufa, Patience Date: Mar 2024 SARS-CoV-2 is a threat to public health due to its ability to undergo crucial mutations, increasing its infectivity and decreasing the vaccine's effectiveness. There is a need to find and introduce alternative and effective methods of controlling ... Read more
The effects of low level laser therapy on both HIV-1 infected and uninfected TZM-bl cells

Author: Lugongolo, Masixole Y ; Manoto, Sello L ; Ombinda-Lemboumba, Saturnin ; Maaza, M ; Mthunzi-Kufa, Patience Date: Jan 2017 Human immunodeficiency virus (HIV-1) infection remains a major health problem despite the use of highly active antiretroviral therapy (HAART), which has greatly reduced mortality rates. Due to the unavailability of an effective vaccine and ... Read more
The efficiency of surface plasmon resonance in measuring human immunodeficiency virus concentrations

Author: Lugongolo, Masoxile Y ; Ombinda-Lemboumba, Saturnin ; Nomcebo Thwala, Nomcebo L ; Tjale, Mabotse A ; Mcoy, Michael P ; Mthunzi-Kufa, Patience Date: Jan 2024 Surface plasmon resonance is a label free optical detection technique, which responds to refractive index variations that are induced by molecular binding incidents or binding affinities. This occurrence takes place when electrons on a thin ... Read more
Efficient femtosecond driven SOX 17 delivery into mouse embryonic stem cells: Differentiation study

Author: Thobakgale, Setumo L ; Manoto, Sello L ; Ombinda-Lemboumba, Saturnin ; Maaza, M ; Mthunzi-Kufa, Patience Date: Jan 2017 Embryonic stem cells have great promise in regenerative medicine because of their ability to self-renew and differentiate into various cell types. Delivery of therapeutic genes into cells has already been achieved using of chemical agents and ... Read more
Enhanced photo-transfection efficiency of mammalian cells on graphene coated substrates

Author: Mthunzi-Kufa, Patience ; He, K ; Ngcobo, Sandile ; Warner, JW Date: Feb 2014 Literature reports graphene, an atomic-thick sheet of carbon atoms as one of the promising biocompatible scaffolds that promotes cellular proliferation in human mesenchymal stem cells. On the other hand, different mammalian cell lines including ... Read more
Evaluation of the photophysicochemical properties and photodynamic therapy activity of nanoconjugates of zinc phthalocyanine linked to glutathione capped Au and Au3Ag1 nanoparticles

Author: Oluwole, DA ; Manoto, Sello L ; Malabi, Rudzani ; Maphanga, Charles P ; Ombinda-Lemboumba, Saturnin ; Mthunzi-Kufa, Patience ; Nyokong, T Date: Mar 2018 We report on the synthesis of glutathione capped gold (AuNPs–GSH) and gold–silver (Au3Ag1NPs–GSH) nanoparticles and their covalent attachment to Zn monocarboxyphenoxy phthalocyanine (1) via amide bond formation. The photophysicochemical ... Read more
Examining HIV infected cells using optical trapping and Raman spectroscopy

Author: Lugongolo, Masixole Y ; Ombinda-Lemboumba, Saturnin ; Manoto, Sello L ; Mthunzi-Kufa, Patience Date: Sep 2021 Manipulation of biological cells using optical trapping is a non-invasive approach in which individual living cells are examined without causing any damage because there is no direct mechanical contact with cells. Optical trapping uses a ... Read more

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