Swai, HHillie, KTCingo, NKalombo, LonjiLegodi, MSemete, B2008-12-102008-12-102006-02Swai, H, Hillie, KT, Cingo, N, Kalombo, L, Legodi, M and Semete, B. 2006. Evaluation of nano encapsulation techniques in different polymeric system for the delivery of anti-tuberculosis drugs (ATD). CSIR Research and Innovation Conference: 1st CSIR Biennial Conference, CSIR International Convention Centre Pretoria, 27-28 February 2006, pp1http://hdl.handle.net/10204/2697CSIR Research and Innovation Conference: 1st CSIR Biennial Conference, CSIR International Convention Centre Pretoria, 27-28 February 2006In this study, isoniazid, one of the most potent anti-TB drugs, was successfully encapsulated in poly (D, L- lactide-co-glycolide) (PLG) and in alginate-chitosan polymeric systems using a double-emulsion method and a cation-induced gelation method, respectively. The formulations from both systems were spray dried to obtain free-flowing powder. For the PLG system, an increase in the temperature of the inlet drying air resulted in decreased particle size, as well as increased absolute zeta potential (surface charge) and encapsulation efficiency, whereas the alginate-chitosan system showed a decrease in the particle size, absolute zeta potential and encapsulation efficiency. The PLG system gave superior results, compared with the alginate-chitosan system, in terms of size, shape, absolute zeta potential and encapsulation efficiencyenAnti-tuberculosis drugsNano encapsulation techniquesNanoparticlesPoly (D, L-lactide-co-glycolide)ATDPLGConference PresentationSwai, H., Hillie, K., Cingo, N., Kalombo, L., Legodi, M., & Semete, B. (2006). Evaluation of nano encapsulation techniques in different polymeric system for the delivery of anti-tuberculosis drugs (ATD). http://hdl.handle.net/10204/2697Swai, H, KT Hillie, N Cingo, Lonji Kalombo, M Legodi, and B Semete. "Evaluation of nano encapsulation techniques in different polymeric system for the delivery of anti-tuberculosis drugs (ATD)." (2006): http://hdl.handle.net/10204/2697Swai H, Hillie K, Cingo N, Kalombo L, Legodi M, Semete B, Evaluation of nano encapsulation techniques in different polymeric system for the delivery of anti-tuberculosis drugs (ATD); 2006. http://hdl.handle.net/10204/2697 .TY - Conference Presentation AU - Swai, H AU - Hillie, KT AU - Cingo, N AU - Kalombo, Lonji AU - Legodi, M AU - Semete, B AB - In this study, isoniazid, one of the most potent anti-TB drugs, was successfully encapsulated in poly (D, L- lactide-co-glycolide) (PLG) and in alginate-chitosan polymeric systems using a double-emulsion method and a cation-induced gelation method, respectively. The formulations from both systems were spray dried to obtain free-flowing powder. For the PLG system, an increase in the temperature of the inlet drying air resulted in decreased particle size, as well as increased absolute zeta potential (surface charge) and encapsulation efficiency, whereas the alginate-chitosan system showed a decrease in the particle size, absolute zeta potential and encapsulation efficiency. The PLG system gave superior results, compared with the alginate-chitosan system, in terms of size, shape, absolute zeta potential and encapsulation efficiency DA - 2006-02 DB - ResearchSpace DP - CSIR KW - Anti-tuberculosis drugs KW - Nano encapsulation techniques KW - Nanoparticles KW - Poly (D, L-lactide-co-glycolide) KW - ATD KW - PLG LK - https://researchspace.csir.co.za PY - 2006 T1 - Evaluation of nano encapsulation techniques in different polymeric system for the delivery of anti-tuberculosis drugs (ATD) TI - Evaluation of nano encapsulation techniques in different polymeric system for the delivery of anti-tuberculosis drugs (ATD) UR - http://hdl.handle.net/10204/2697 ER -