Van der Westhuyzen, Christiaan WParkinson, CJ2007-06-292007-06-292005Van der Westhuyzen, CW and Parkinson, CJ. 2005. Synthesis of a structurally constrained endoperoxide having antimalarial activity from alpha-santonin. South African Journal of Chemistry, vol. 58, pp 41-450379-4350http://hdl.handle.net/10204/763Copyright: 2005 Bureau Scientific PublicationsAlpha-Santonin 3 was successfully converted into a biologically active compound 5b containing an endoperoxide group through a photo-oxygenation approach as a single isomer. It was found that the singlet oxygen afforded the isomer produced by attack from the sterically-hindered face of cyclohexadiene derivative 4. Evidence to this end is presented based on NOE results and the products formed in the photo-oxygenation reaction, as well as the in vitro testing of 5b for antimalarial activity.enSinglet oxygenSantoninPhoto-oxygenatedEndoperoxideArticleVan der Westhuyzen, C. W., & Parkinson, C. (2005). Synthesis of a structurally constrained endoperoxide having antimalarial activity from alpha-santonin. http://hdl.handle.net/10204/763Van der Westhuyzen, Christiaan W, and CJ Parkinson "Synthesis of a structurally constrained endoperoxide having antimalarial activity from alpha-santonin." (2005) http://hdl.handle.net/10204/763Van der Westhuyzen CW, Parkinson C. Synthesis of a structurally constrained endoperoxide having antimalarial activity from alpha-santonin. 2005; http://hdl.handle.net/10204/763.TY - Article AU - Van der Westhuyzen, Christiaan W AU - Parkinson, CJ AB - Alpha-Santonin 3 was successfully converted into a biologically active compound 5b containing an endoperoxide group through a photo-oxygenation approach as a single isomer. It was found that the singlet oxygen afforded the isomer produced by attack from the sterically-hindered face of cyclohexadiene derivative 4. Evidence to this end is presented based on NOE results and the products formed in the photo-oxygenation reaction, as well as the in vitro testing of 5b for antimalarial activity. DA - 2005 DB - ResearchSpace DP - CSIR KW - Singlet oxygen KW - Santonin KW - Photo-oxygenated KW - Endoperoxide LK - https://researchspace.csir.co.za PY - 2005 SM - 0379-4350 T1 - Synthesis of a structurally constrained endoperoxide having antimalarial activity from alpha-santonin TI - Synthesis of a structurally constrained endoperoxide having antimalarial activity from alpha-santonin UR - http://hdl.handle.net/10204/763 ER -