Nombona, NMaduray, KAntunes, EKarsten, ANyokong, T2012-03-082012-03-082012-02Nombona, N, Maduray, K, Antunes, E, Karsten, A and Nyokong, T. 2012. Synthesis of phthalocyanine conjugates with gold nanoparticles and liposomes for photodynamic therapy. Journal of Photochemistry and Photobiology B: Biology, vol. 107, pp 35-441011-1344http://www.sciencedirect.com/science/article/pii/S101113441100251Xhttp://hdl.handle.net/10204/5632Copyright: 2012 Elsevier. This is an ABSTRACT ONLYThe efficiency of [2,9,17,23-tetrakis-(1,6-hexanedithiol)phthalocyaninato]zinc(II) as a photodynamic therapy (PDT) agent was investigated. This compound belongs to the second generation of photosensitizers currently tested for the cellular photo-damage of cancer cells. The production of reactive oxygen species (ROS) and phototoxicity of the photosensitizer were assessed. Healthy fibroblast cells and breast cancer (MCF-7) cells were treated with either free phthalocyanine or phthalocyanine bound to either gold nanoparticles or encapsulated in liposomes. Cell viability studies showed the optimum phototoxic effect on non-malignant cells to be 4.5 J cm-2. The PDT effect of the liposome bound phthalocyanine showed extensive damage of the breast cancer cells. Gold nanoparticles only showed a modest improvement in PDT activity.enPhthalocyanineGold nanoparticlesLiposomesPhotodynamic therapyArticleNombona, N., Maduray, K., Antunes, E., Karsten, A., & Nyokong, T. (2012). Synthesis of phthalocyanine conjugates with gold nanoparticles and liposomes for photodynamic therapy. http://hdl.handle.net/10204/5632Nombona, N, K Maduray, E Antunes, A Karsten, and T Nyokong "Synthesis of phthalocyanine conjugates with gold nanoparticles and liposomes for photodynamic therapy." (2012) http://hdl.handle.net/10204/5632Nombona N, Maduray K, Antunes E, Karsten A, Nyokong T. Synthesis of phthalocyanine conjugates with gold nanoparticles and liposomes for photodynamic therapy. 2012; http://hdl.handle.net/10204/5632.TY - Article AU - Nombona, N AU - Maduray, K AU - Antunes, E AU - Karsten, A AU - Nyokong, T AB - The efficiency of [2,9,17,23-tetrakis-(1,6-hexanedithiol)phthalocyaninato]zinc(II) as a photodynamic therapy (PDT) agent was investigated. This compound belongs to the second generation of photosensitizers currently tested for the cellular photo-damage of cancer cells. The production of reactive oxygen species (ROS) and phototoxicity of the photosensitizer were assessed. Healthy fibroblast cells and breast cancer (MCF-7) cells were treated with either free phthalocyanine or phthalocyanine bound to either gold nanoparticles or encapsulated in liposomes. Cell viability studies showed the optimum phototoxic effect on non-malignant cells to be 4.5 J cm-2. The PDT effect of the liposome bound phthalocyanine showed extensive damage of the breast cancer cells. Gold nanoparticles only showed a modest improvement in PDT activity. DA - 2012-02 DB - ResearchSpace DP - CSIR KW - Phthalocyanine KW - Gold nanoparticles KW - Liposomes KW - Photodynamic therapy LK - https://researchspace.csir.co.za PY - 2012 SM - 1011-1344 T1 - Synthesis of phthalocyanine conjugates with gold nanoparticles and liposomes for photodynamic therapy TI - Synthesis of phthalocyanine conjugates with gold nanoparticles and liposomes for photodynamic therapy UR - http://hdl.handle.net/10204/5632 ER -