Van Wyk, LTNeyt, Nicole CJugmohan, JaimeePanayides, Jenny-LeeRiley, DL2024-03-192024-03-192024-01Van Wyk, L., Neyt, N.C., Jugmohan, J., Panayides, J. & Riley, D. 2024. The synthesis of bupropion hydrochloride under greener and safer conditions utilizing flow technologies. <i>Reaction Chemistry & Engineering, 9.</i> http://hdl.handle.net/10204/136472058-9883https://doi.org/10.1039/d3re00443khttp://hdl.handle.net/10204/13647Globally, major depressive disorders are a leading cause of disconsolateness affecting more than 300 million individuals. Bupropion is a unique dopamine-norepinephrine reuptake inhibitor (DNRI) commonly utilized in the treatment of depression, smoking cessation, ADHD and other addictions. Herein, we report our attempts to develop a greener, safer and more sustainable process for the preparation of bupropion hydrochloride employing flow chemistry. The use of obnoxious and corrosive liquid bromine was evaded through the employment of polymer-bound pyridinium tribromide and environmentally questionable solvents NMP and DMF were substituted with greener co-solvent systems with appreciable success. The final telescoped flow process afforded bupropion hydrochloride in a 69% overall yield, with improved process mass intensity, productivity and purity, as well as a reduction in reagents/solvents designated as red or amber in terms of H-codes.FulltextenMajor depressive disorderMDDClinical depressionBupropion hydrochlorideArticleVan Wyk, L., Neyt, N. C., Jugmohan, J., Panayides, J., & Riley, D. (2024). The synthesis of bupropion hydrochloride under greener and safer conditions utilizing flow technologies. <i>Reaction Chemistry & Engineering, 9</i>, http://hdl.handle.net/10204/13647Van Wyk, LT, Nicole C Neyt, Jaimee Jugmohan, Jenny-Lee Panayides, and DL Riley "The synthesis of bupropion hydrochloride under greener and safer conditions utilizing flow technologies." <i>Reaction Chemistry & Engineering, 9</i> (2024) http://hdl.handle.net/10204/13647Van Wyk L, Neyt NC, Jugmohan J, Panayides J, Riley D. The synthesis of bupropion hydrochloride under greener and safer conditions utilizing flow technologies. Reaction Chemistry & Engineering, 9. 2024; http://hdl.handle.net/10204/13647.TY - Article AU - Van Wyk, LT AU - Neyt, Nicole C AU - Jugmohan, Jaimee AU - Panayides, Jenny-Lee AU - Riley, DL AB - Globally, major depressive disorders are a leading cause of disconsolateness affecting more than 300 million individuals. Bupropion is a unique dopamine-norepinephrine reuptake inhibitor (DNRI) commonly utilized in the treatment of depression, smoking cessation, ADHD and other addictions. Herein, we report our attempts to develop a greener, safer and more sustainable process for the preparation of bupropion hydrochloride employing flow chemistry. The use of obnoxious and corrosive liquid bromine was evaded through the employment of polymer-bound pyridinium tribromide and environmentally questionable solvents NMP and DMF were substituted with greener co-solvent systems with appreciable success. The final telescoped flow process afforded bupropion hydrochloride in a 69% overall yield, with improved process mass intensity, productivity and purity, as well as a reduction in reagents/solvents designated as red or amber in terms of H-codes. DA - 2024-01 DB - ResearchSpace DP - CSIR J1 - Reaction Chemistry & Engineering, 9 KW - Major depressive disorder KW - MDD KW - Clinical depression KW - Bupropion hydrochloride LK - https://researchspace.csir.co.za PY - 2024 SM - 2058-9883 T1 - The synthesis of bupropion hydrochloride under greener and safer conditions utilizing flow technologies TI - The synthesis of bupropion hydrochloride under greener and safer conditions utilizing flow technologies UR - http://hdl.handle.net/10204/13647 ER -27712