Pillay, PNaidoo, DashnieMaharaj, VJMoodley, NSewnarain, PVan Rooyen, SMthembu, XKhorombi, E2008-11-132008-11-132008-11Pillay, P, Naidoo, D, Maharaj, VJ et al. 2008. South African plants as a source of drugs to treat infectious diseases - TB, malaria and HIV. Science real and relevant: 2nd CSIR Biennial Conference, CSIR International Convention Centre Pretoria, 17&18 November 2008, pp 4http://hdl.handle.net/10204/2540Science real and relevant: 2nd CSIR Biennial Conference, CSIR International Convention Centre Pretoria, 17&18 November 2008CSIR Biosciences is actively involved in identifying new medicines effective against tuberculosis (TB), malaria and HIV based on South Africa’s rich biodiversity. As part of a national multidisciplinary consortium, the Bioprospecting research group and the South African National Biodiversity Institute (SANBI) established a database of 566 plant taxa that are reportedly used for the treatment of TB and 623 taxa associated with malaria and/or fever. A process of prioritization using selection criteria led to 162 plant extracts, representing 24 taxa, being tested in a preliminary in vitro screen against Mycobacterium aurum. Thirteen extracts demonstrated significant antibacterial activity and were subsequently tested against M. tuberculosis. This led to 7 extracts (5 taxa) with significant anti- TB activity. Of the 134 plant taxa tested for in vitro antimalarial activity against a chloroquine-sensitive strain of Plasmodium falciparum, 23 species were found to be highly active. Bioprospecting has screened 30 plants with traditional use related to the treatment of HIV for their anti-HIV properties, resulting in the identification of four biologically active plant extracts (4 taxa), which are currently being further developed. A recent research collaboration with Esperanza Medicines Foundation (EMF) also provided a unique opportunity to evaluate South African medicinal plants in HIV/AIDS-related biological assays exclusive to the Swiss-based institute. Overall, compelling evidence has been provided for the rational exploration of South African plants as sources of new drugs to treat TB, malaria and HIVenInfectious diseasesMalariaTuberculosisHIVPlant extractsDrugConference PresentationPillay, P., Naidoo, D., Maharaj, V., Moodley, N., Sewnarain, P., Van Rooyen, S., ... Khorombi, E. (2008). South African plants as a source of drugs to treat infectious diseases - TB, malaria and HIV. http://hdl.handle.net/10204/2540Pillay, P, Dashnie Naidoo, VJ Maharaj, N Moodley, P Sewnarain, S Van Rooyen, X Mthembu, and E Khorombi. "South African plants as a source of drugs to treat infectious diseases - TB, malaria and HIV." (2008): http://hdl.handle.net/10204/2540Pillay P, Naidoo D, Maharaj V, Moodley N, Sewnarain P, Van Rooyen S, et al, South African plants as a source of drugs to treat infectious diseases - TB, malaria and HIV; 2008. http://hdl.handle.net/10204/2540 .TY - Conference Presentation AU - Pillay, P AU - Naidoo, Dashnie AU - Maharaj, VJ AU - Moodley, N AU - Sewnarain, P AU - Van Rooyen, S AU - Mthembu, X AU - Khorombi, E AB - CSIR Biosciences is actively involved in identifying new medicines effective against tuberculosis (TB), malaria and HIV based on South Africa’s rich biodiversity. As part of a national multidisciplinary consortium, the Bioprospecting research group and the South African National Biodiversity Institute (SANBI) established a database of 566 plant taxa that are reportedly used for the treatment of TB and 623 taxa associated with malaria and/or fever. A process of prioritization using selection criteria led to 162 plant extracts, representing 24 taxa, being tested in a preliminary in vitro screen against Mycobacterium aurum. Thirteen extracts demonstrated significant antibacterial activity and were subsequently tested against M. tuberculosis. This led to 7 extracts (5 taxa) with significant anti- TB activity. Of the 134 plant taxa tested for in vitro antimalarial activity against a chloroquine-sensitive strain of Plasmodium falciparum, 23 species were found to be highly active. Bioprospecting has screened 30 plants with traditional use related to the treatment of HIV for their anti-HIV properties, resulting in the identification of four biologically active plant extracts (4 taxa), which are currently being further developed. A recent research collaboration with Esperanza Medicines Foundation (EMF) also provided a unique opportunity to evaluate South African medicinal plants in HIV/AIDS-related biological assays exclusive to the Swiss-based institute. Overall, compelling evidence has been provided for the rational exploration of South African plants as sources of new drugs to treat TB, malaria and HIV DA - 2008-11 DB - ResearchSpace DP - CSIR KW - Infectious diseases KW - Malaria KW - Tuberculosis KW - HIV KW - Plant extracts KW - Drug LK - https://researchspace.csir.co.za PY - 2008 T1 - South African plants as a source of drugs to treat infectious diseases - TB, malaria and HIV TI - South African plants as a source of drugs to treat infectious diseases - TB, malaria and HIV UR - http://hdl.handle.net/10204/2540 ER -