Pillay, VMashingaidze, FChoonara, YEDu Toit, LCBuckmann, EMaharaj, VNdesendo, VMKKumar, P2012-06-142012-06-142012-06Pillay, V, Mashingaidze, F, Choonara, YE, Du Toit, LC, Buckmann, E, Maharaj, V, Ndesendo, VMK and Kumar, P. 2012. Qualitative and quantitative intravaginal targeting: Key to anti-HIV-1 microbicide delivery from test tube to in vivo success. Journal of Pharmaceutical Sciences, vol. 101(6), pp 1950-19680022-3549http://onlinelibrary.wiley.com/doi/10.1002/jps.23098/abstracthttp://onlinelibrary.wiley.com/doi/10.1002/jps.23098/pdfhttp://hdl.handle.net/10204/5906Copyright: 2012 Wiley Periodicals, Inc. and the American Pharmacists Association. This is an ABSTRACT ONLY.The past decade has seen several effective anti-HIV-1 agent discoveries, yet microbicides continue to disappoint clinically. Our review expounds the view that unsatisfactory microbicide failures may be a result of inefficient delivery systems employed. We hereby propose a thorough scientific qualitative and quantitative investigation of important aspects involved in HIV-1 transmission as a prerequisite for microbicide delivery. Intravaginal targeting of HIV-1 increases the chances of microbicide success, wherein vaginal microenvironmental factors including pH should be maintained at HIV-1 prohibitive acidic levels simultaneously to ward off other sexually transmitted diseases, which compromise vaginal epithelial barrier properties. Furthermore, choice of receptors to target both on HIV-1 and on target cells is vital in deterring transmission. Appropriate modeling of virus–target cell interactions as well as targeting early stages of the HIV-1 infection accompanied by computation and delivery of appropriate microbicide quantities could revolutionize microbicide research, ultimately delivering a female-controlled HIV-1 prevention modality appropriately.enTargeted drug deliverySpecial populationsSite-specific deliveryPolymeric drug delivery systemsPolymer–biopolymer interactionsPhysicochemical propertiesPharmacokineticsPharmacodynamicsPermeabilityMucosal deliveryMacromolecular drug deliveryArticlePillay, V., Mashingaidze, F., Choonara, Y., Du Toit, L., Buckmann, E., Maharaj, V., ... Kumar, P. (2012). Qualitative and quantitative intravaginal targeting: Key to anti-HIV-1 microbicide delivery from test tube to in vivo success. http://hdl.handle.net/10204/5906Pillay, V, F Mashingaidze, YE Choonara, LC Du Toit, E Buckmann, V Maharaj, VMK Ndesendo, and P Kumar "Qualitative and quantitative intravaginal targeting: Key to anti-HIV-1 microbicide delivery from test tube to in vivo success." (2012) http://hdl.handle.net/10204/5906Pillay V, Mashingaidze F, Choonara Y, Du Toit L, Buckmann E, Maharaj V, et al. Qualitative and quantitative intravaginal targeting: Key to anti-HIV-1 microbicide delivery from test tube to in vivo success. 2012; http://hdl.handle.net/10204/5906.TY - Article AU - Pillay, V AU - Mashingaidze, F AU - Choonara, YE AU - Du Toit, LC AU - Buckmann, E AU - Maharaj, V AU - Ndesendo, VMK AU - Kumar, P AB - The past decade has seen several effective anti-HIV-1 agent discoveries, yet microbicides continue to disappoint clinically. Our review expounds the view that unsatisfactory microbicide failures may be a result of inefficient delivery systems employed. We hereby propose a thorough scientific qualitative and quantitative investigation of important aspects involved in HIV-1 transmission as a prerequisite for microbicide delivery. Intravaginal targeting of HIV-1 increases the chances of microbicide success, wherein vaginal microenvironmental factors including pH should be maintained at HIV-1 prohibitive acidic levels simultaneously to ward off other sexually transmitted diseases, which compromise vaginal epithelial barrier properties. Furthermore, choice of receptors to target both on HIV-1 and on target cells is vital in deterring transmission. Appropriate modeling of virus–target cell interactions as well as targeting early stages of the HIV-1 infection accompanied by computation and delivery of appropriate microbicide quantities could revolutionize microbicide research, ultimately delivering a female-controlled HIV-1 prevention modality appropriately. DA - 2012-06 DB - ResearchSpace DP - CSIR KW - Targeted drug delivery KW - Special populations KW - Site-specific delivery KW - Polymeric drug delivery systems KW - Polymer–biopolymer interactions KW - Physicochemical properties KW - Pharmacokinetics KW - Pharmacodynamics KW - Permeability KW - Mucosal delivery KW - Macromolecular drug delivery LK - https://researchspace.csir.co.za PY - 2012 SM - 0022-3549 T1 - Qualitative and quantitative intravaginal targeting: Key to anti-HIV-1 microbicide delivery from test tube to in vivo success TI - Qualitative and quantitative intravaginal targeting: Key to anti-HIV-1 microbicide delivery from test tube to in vivo success UR - http://hdl.handle.net/10204/5906 ER -