HIV-1 subtype C primary isolates exhibit high sensitivity to an anti-gp120 RNA aptamer

Mufhandu, Hazel TAlexandre, Kabamba BGray, ESMorris, LKhati, M2012-11-142012-11-142012-09Mufhandu, HT, Alexandre, KB, Gray, ES, Morris, L and Khati, M. 2012. HIV-1 subtype C primary isolates exhibit high sensitivity to an anti-gp120 RNA aptamer. Retrovirology, vol. 9 (supplement 2), p. 2151742-4690http://www.retrovirology.com/content/pdf/1742-4690-9-S2-P215.pdfhttp://hdl.handle.net/10204/6312Copyright: 2012 Mufhandu et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Globally, HIV-1 subtype C is the most prevalent subtype, yet most antiretroviral drugs are developed against subtype B. UCLA1 RNA aptamer, which we previously showed neutralizes HIV-1 subtype C Env-pseudotyped viruses was examined for neutralization of subtype C primary isolates in PBMC and monocyte-derived macrophages (MDM). We also assessed the ability of subtype C to develop resistance to UCLA1 inhibition by propagating the isolates in increasing concentrations of the aptamer.enHIV-1 gp120UCLA-1 AptamerAntiretroviral drugsHIV-1 subtype C primary isolates exhibit high sensitivity to an anti-gp120 RNA aptamerArticleMufhandu, H. T., Alexandre, K. B., Gray, E., Morris, L., & Khati, M. (2012). HIV-1 subtype C primary isolates exhibit high sensitivity to an anti-gp120 RNA aptamer. http://hdl.handle.net/10204/6312Mufhandu, Hazel T, Kabamba B Alexandre, ES Gray, L Morris, and M Khati "HIV-1 subtype C primary isolates exhibit high sensitivity to an anti-gp120 RNA aptamer." (2012) http://hdl.handle.net/10204/6312Mufhandu HT, Alexandre KB, Gray E, Morris L, Khati M. HIV-1 subtype C primary isolates exhibit high sensitivity to an anti-gp120 RNA aptamer. 2012; http://hdl.handle.net/10204/6312.TY - Article AU - Mufhandu, Hazel T AU - Alexandre, Kabamba B AU - Gray, ES AU - Morris, L AU - Khati, M AB - Globally, HIV-1 subtype C is the most prevalent subtype, yet most antiretroviral drugs are developed against subtype B. UCLA1 RNA aptamer, which we previously showed neutralizes HIV-1 subtype C Env-pseudotyped viruses was examined for neutralization of subtype C primary isolates in PBMC and monocyte-derived macrophages (MDM). We also assessed the ability of subtype C to develop resistance to UCLA1 inhibition by propagating the isolates in increasing concentrations of the aptamer. DA - 2012-09 DB - ResearchSpace DP - CSIR KW - HIV-1 gp120 KW - UCLA-1 Aptamer KW - Antiretroviral drugs LK - https://researchspace.csir.co.za PY - 2012 SM - 1742-4690 T1 - HIV-1 subtype C primary isolates exhibit high sensitivity to an anti-gp120 RNA aptamer TI - HIV-1 subtype C primary isolates exhibit high sensitivity to an anti-gp120 RNA aptamer UR - http://hdl.handle.net/10204/6312 ER -