Van der Westhuyzen, Christiaan WRousseau, ALParkinson, CJ2007-10-232007-10-232007Van der Westhuyzen, CW, Rousseau, AL and Parkinson, CJ. 2007. Effect of substituent structure on pyrimidine electrophilic substitution. Tetrahedron -London, Vol. 63, pp 5394-54050040-4020http://hdl.handle.net/10204/1370Copyright: 2007 Elsevier Science B.VIn an investigation into the electrophilic nitrosation reactions of a series of 4,6-disubstituted pyrimidine derivatives, a subtle interplay between the electronic nature of the C-4 and C-6 substituents and reactivity was found where these were chloro-, mono- or disubstituted amino groups. Effects such as the presence of an aryl group or two alkyl groups on the amino moiety impede the progress of the reaction despite the presence of a second activating group.enPyrimidineElectrophilic nitrosationAmino groupsAryl groupAlkyl groupArticleVan der Westhuyzen, C. W., Rousseau, A., & Parkinson, C. (2007). Effect of substituent structure on pyrimidine electrophilic substitution. http://hdl.handle.net/10204/1370Van der Westhuyzen, Christiaan W, AL Rousseau, and CJ Parkinson "Effect of substituent structure on pyrimidine electrophilic substitution." (2007) http://hdl.handle.net/10204/1370Van der Westhuyzen CW, Rousseau A, Parkinson C. Effect of substituent structure on pyrimidine electrophilic substitution. 2007; http://hdl.handle.net/10204/1370.TY - Article AU - Van der Westhuyzen, Christiaan W AU - Rousseau, AL AU - Parkinson, CJ AB - In an investigation into the electrophilic nitrosation reactions of a series of 4,6-disubstituted pyrimidine derivatives, a subtle interplay between the electronic nature of the C-4 and C-6 substituents and reactivity was found where these were chloro-, mono- or disubstituted amino groups. Effects such as the presence of an aryl group or two alkyl groups on the amino moiety impede the progress of the reaction despite the presence of a second activating group. DA - 2007 DB - ResearchSpace DP - CSIR KW - Pyrimidine KW - Electrophilic nitrosation KW - Amino groups KW - Aryl group KW - Alkyl group LK - https://researchspace.csir.co.za PY - 2007 SM - 0040-4020 T1 - Effect of substituent structure on pyrimidine electrophilic substitution TI - Effect of substituent structure on pyrimidine electrophilic substitution UR - http://hdl.handle.net/10204/1370 ER -