Hata, YEbrahimi, SNDe Mieri, MZimmermann, SMokoka, TNaidoo, DashnieFouché, GerdaMaharajKaiser, MBrun, RPotterat, OHamburger, M2014-06-172014-06-172014-03Hata, Y, Ebrahimi, S.N, De Mieri, M, Zimmermann, S, Mokoka, T, Naidoo, D, Fouche, G, Maharaj, V, Kaiser, M, Brun, R, Potterat, O and Hamburger, M. 2014. Antitrypanosomal isoflavan quinones from Abrus precatorius. Fitoterapia, vol. 93, pp 81-870367-326Xhttp://ac.els-cdn.com/S0367326X13003249/1-s2.0-S0367326X13003249-main.pdf?_tid=2758918c-f16d-11e3-ba48-00000aab0f02&acdnat=1402493866_dee86fd3c158a9fe39f95a00211baa3dhttp://hdl.handle.net/10204/7445Copyright: 2014 Elsevier. This is an ABSTRACT ONLY. The definitive version is published in Fitoterapia, vol. 93, pp 81-87Human African trypanosomiasis is a neglected tropical disease in sub Saharan Africa that is fatal if left untreated. In a search for new natural products with antitrypanosomal activity, we recently identified abruquinones B and I from Abrus precatorius as potent in vitro trypanocidal compounds with high selectivity indices. To obtain sufficient compound for in vivo efficacy tests in mice, a second batch of plant material was re-collected and extracted. However, the chemical profiles of the two batches differed, and additional abruquinoneswere isolated and identified by HR-ESI-MS, and 1D and 2D NMR (sup1)H, (sup13)C, COSY, HMBC, HSQC, and NOESY) spectroscopy. Abruquinones J (1), K (2), and L (3)were new,while abruquinones A (4) and D (5)were known from the first batch of plant material. The absolute configuration of compounds 1 to 3was determined by comparison of electronic circular dichroism (ECD) spectra with calculated ECD data. Compounds 2 to 5 showed high in vitro activity against T. b. rhodesiense (IC(sub50) of 0.01, 0.02, 0.02 and 0.01 µM, respectively), and remarkable SIs of 508, 374, 1379, and 668, respectively.enTrypanosoma brucei rhodesienseIsoflavan quinoneAbrus precatoriusFabaceaeHuman African trypanosomiasisHATArticleHata, Y., Ebrahimi, S., De Mieri, M., Zimmermann, S., Mokoka, T., Naidoo, D., ... Hamburger, M. (2014). Antitrypanosomal isoflavan quinones from Abrus precatorius. http://hdl.handle.net/10204/7445Hata, Y, SN Ebrahimi, M De Mieri, S Zimmermann, T Mokoka, Dashnie Naidoo, Gerda Fouché, et al "Antitrypanosomal isoflavan quinones from Abrus precatorius." (2014) http://hdl.handle.net/10204/7445Hata Y, Ebrahimi S, De Mieri M, Zimmermann S, Mokoka T, Naidoo D, et al. Antitrypanosomal isoflavan quinones from Abrus precatorius. 2014; http://hdl.handle.net/10204/7445.TY - Article AU - Hata, Y AU - Ebrahimi, SN AU - De Mieri, M AU - Zimmermann, S AU - Mokoka, T AU - Naidoo, Dashnie AU - Fouché, Gerda AU - Maharaj AU - Kaiser, M AU - Brun, R AU - Potterat, O AU - Hamburger, M AB - Human African trypanosomiasis is a neglected tropical disease in sub Saharan Africa that is fatal if left untreated. In a search for new natural products with antitrypanosomal activity, we recently identified abruquinones B and I from Abrus precatorius as potent in vitro trypanocidal compounds with high selectivity indices. To obtain sufficient compound for in vivo efficacy tests in mice, a second batch of plant material was re-collected and extracted. However, the chemical profiles of the two batches differed, and additional abruquinoneswere isolated and identified by HR-ESI-MS, and 1D and 2D NMR (sup1)H, (sup13)C, COSY, HMBC, HSQC, and NOESY) spectroscopy. Abruquinones J (1), K (2), and L (3)were new,while abruquinones A (4) and D (5)were known from the first batch of plant material. The absolute configuration of compounds 1 to 3was determined by comparison of electronic circular dichroism (ECD) spectra with calculated ECD data. Compounds 2 to 5 showed high in vitro activity against T. b. rhodesiense (IC(sub50) of 0.01, 0.02, 0.02 and 0.01 µM, respectively), and remarkable SIs of 508, 374, 1379, and 668, respectively. DA - 2014-03 DB - ResearchSpace DP - CSIR KW - Trypanosoma brucei rhodesiense KW - Isoflavan quinone KW - Abrus precatorius KW - Fabaceae KW - Human African trypanosomiasis KW - HAT LK - https://researchspace.csir.co.za PY - 2014 SM - 0367-326X T1 - Antitrypanosomal isoflavan quinones from Abrus precatorius TI - Antitrypanosomal isoflavan quinones from Abrus precatorius UR - http://hdl.handle.net/10204/7445 ER -