Moolman, FSLabuschagne, Philip WThantsa, MSVan der Merwe, TLRolfes, HCloete, TE2007-08-062007-08-062006Moolman, FS, Labuschagne, PW, Thantsa, MS, Van der Merwe, TL, Rolfes, H and Cloete, TE. 2006. Encapsulating probiotics with an interpolymer complex in supercritical carbon dioxide. South African Journal of Science, Vol. 102(7/8), pp 349-3540038-2353http://hdl.handle.net/10204/1086Copyright: 2006 Acad Science South Africa A S S AFTraditional encapsulation methods in fortified foods and drug delivery applications present difficulties for ‘actives’, such as probiotics, sensitive to exposure to water, solvents, heat or oxygen, where ‘active’ refers to a material, chemical or organism that has some potential benefit when consumed. In this paper authors present a novel encapsulation technology, based on interpolymer complex formation in supercritical carbon dioxide, which avoids such exposure during the encapsulation process. The method was used to encapsulate indomethacin and Bifidobacterium longum in a poly(vinyl pyrrolidone)–poly(vinyl acetate–co-crotonic acid) interpolymer complex. Polymer complexation was confirmed by Fourier Transform infrared and moisture absorption studies. Polymer plasticization and release of encapsulated probiotics were studied with scanning electron microscopy. It was shown that the encapsulation matrix is stable at low pH, but disintegrates at higher pH, triggering release of the encapsulated material. The technology could find application in encapsulation of sensitive actives in the food and pharmaceutical industryenBacterial enumerationProbioticsEncapsulation technologyArticleMoolman, F., Labuschagne, P. W., Thantsa, M., Van der Merwe, T., Rolfes, H., & Cloete, T. (2006). Encapsulating probiotics with an interpolymer complex in supercritical carbon dioxide. http://hdl.handle.net/10204/1086Moolman, FS, Philip W Labuschagne, MS Thantsa, TL Van der Merwe, H Rolfes, and TE Cloete "Encapsulating probiotics with an interpolymer complex in supercritical carbon dioxide." (2006) http://hdl.handle.net/10204/1086Moolman F, Labuschagne PW, Thantsa M, Van der Merwe T, Rolfes H, Cloete T. Encapsulating probiotics with an interpolymer complex in supercritical carbon dioxide. 2006; http://hdl.handle.net/10204/1086.TY - Article AU - Moolman, FS AU - Labuschagne, Philip W AU - Thantsa, MS AU - Van der Merwe, TL AU - Rolfes, H AU - Cloete, TE AB - Traditional encapsulation methods in fortified foods and drug delivery applications present difficulties for ‘actives’, such as probiotics, sensitive to exposure to water, solvents, heat or oxygen, where ‘active’ refers to a material, chemical or organism that has some potential benefit when consumed. In this paper authors present a novel encapsulation technology, based on interpolymer complex formation in supercritical carbon dioxide, which avoids such exposure during the encapsulation process. The method was used to encapsulate indomethacin and Bifidobacterium longum in a poly(vinyl pyrrolidone)–poly(vinyl acetate–co-crotonic acid) interpolymer complex. Polymer complexation was confirmed by Fourier Transform infrared and moisture absorption studies. Polymer plasticization and release of encapsulated probiotics were studied with scanning electron microscopy. It was shown that the encapsulation matrix is stable at low pH, but disintegrates at higher pH, triggering release of the encapsulated material. The technology could find application in encapsulation of sensitive actives in the food and pharmaceutical industry DA - 2006 DB - ResearchSpace DP - CSIR KW - Bacterial enumeration KW - Probiotics KW - Encapsulation technology LK - https://researchspace.csir.co.za PY - 2006 SM - 0038-2353 T1 - Encapsulating probiotics with an interpolymer complex in supercritical carbon dioxide TI - Encapsulating probiotics with an interpolymer complex in supercritical carbon dioxide UR - http://hdl.handle.net/10204/1086 ER -