Preclinical assessment addressing intravenous administration of a [68 Ga]Ga-PSMA-617 microemulsion: Acute in vivo toxicity, tolerability, PET imaging, and biodistribution

Mandiwana, VusaniKalombo, LonjiHayeshi, RZeevaart, JREbenhan, T2021-05-192021-05-192021-04Mandiwana, V., Kalombo, L., Hayeshi, R., Zeevaart, J. & Ebenhan, T. 2021. Preclinical assessment addressing intravenous administration of a [68 Ga]Ga-PSMA-617 microemulsion: Acute in vivo toxicity, tolerability, PET imaging, and biodistribution. Molecules, 26(9). http://hdl.handle.net/10204/120141420-3049DOI: 10.3390/molecules26092650http://hdl.handle.net/10204/12014It has been herein presented that a microemulsion, known to be an effective and safe drug delivery system following intravenous administration, can be loaded with traces of [68Ga]Ga-PSMA-617 without losing its properties or causing toxicity. Following tolerated IV injections the capability of the microemulsion in altering [68Ga]Ga-PSMA-617 distribution was presented at 120 min post injection based on its ex vivo biodistribution results.Fulltexten68GaPSMA-617[68Ga]Ga-PSMA-617-MEBiodistributionIn vivoMicroPET/CTProstate cancerPSMA-617ToxicityPreclinical assessment addressing intravenous administration of a [68 Ga]Ga-PSMA-617 microemulsion: Acute in vivo toxicity, tolerability, PET imaging, and biodistributionArticleMandiwana, V., Kalombo, L., Hayeshi, R., Zeevaart, J., & Ebenhan, T. (2021). Preclinical assessment addressing intravenous administration of a [68 Ga]Ga-PSMA-617 microemulsion: Acute in vivo toxicity, tolerability, PET imaging, and biodistribution. Molecules, 26(9), http://hdl.handle.net/10204/12014Mandiwana, Vusani, Lonji Kalombo, R Hayeshi, JR Zeevaart, and T Ebenhan "Preclinical assessment addressing intravenous administration of a [68 Ga]Ga-PSMA-617 microemulsion: Acute in vivo toxicity, tolerability, PET imaging, and biodistribution." Molecules, 26(9) (2021) http://hdl.handle.net/10204/12014Mandiwana V, Kalombo L, Hayeshi R, Zeevaart J, Ebenhan T. Preclinical assessment addressing intravenous administration of a [68 Ga]Ga-PSMA-617 microemulsion: Acute in vivo toxicity, tolerability, PET imaging, and biodistribution. Molecules, 26(9). 2021; http://hdl.handle.net/10204/12014.TY - Article AU - Mandiwana, Vusani AU - Kalombo, Lonji AU - Hayeshi, R AU - Zeevaart, JR AU - Ebenhan, T AB - It has been herein presented that a microemulsion, known to be an effective and safe drug delivery system following intravenous administration, can be loaded with traces of [68Ga]Ga-PSMA-617 without losing its properties or causing toxicity. Following tolerated IV injections the capability of the microemulsion in altering [68Ga]Ga-PSMA-617 distribution was presented at 120 min post injection based on its ex vivo biodistribution results. DA - 2021-04 DB - ResearchSpace DP - CSIR J1 - Molecules, 26(9) KW - 68Ga KW - PSMA-617 KW - [68Ga]Ga-PSMA-617-ME KW - Biodistribution KW - In vivo KW - MicroPET/CT KW - Prostate cancer KW - PSMA-617 KW - Toxicity LK - https://researchspace.csir.co.za PY - 2021 SM - 1420-3049 T1 - Preclinical assessment addressing intravenous administration of a [68 Ga]Ga-PSMA-617 microemulsion: Acute in vivo toxicity, tolerability, PET imaging, and biodistribution TI - Preclinical assessment addressing intravenous administration of a [68 Ga]Ga-PSMA-617 microemulsion: Acute in vivo toxicity, tolerability, PET imaging, and biodistribution UR - http://hdl.handle.net/10204/12014 ER -24534