Oluwole, DAManoto, Sello LMalabi, RudzaniMaphanga, Charles POmbinda-Lemboumba, SaturninMthunzi-Kufa, PatienceNyokong, T2018-01-042018-01-042018-03Oluwole, D.A. et al. 2018. Evaluation of the photophysicochemical properties and photodynamic therapy activity of nanoconjugates of zinc phthalocyanine linked to glutathione capped Au and Au3Ag1 nanoparticles. Dyes and Pigments, vol. 150: 139-1500143-7208https://doi.org/10.1016/j.dyepig.2017.11.019https://www.sciencedirect.com/science/article/pii/S0143720817317552http://hdl.handle.net/10204/9912Copyright: 2017 Elsevier. Due to copyright restrictions, the attached PDF file only contains the abstract of the full text item. For access to the full text item, please consult the publisher's website.We report on the synthesis of glutathione capped gold (AuNPs–GSH) and gold–silver (Au3Ag1NPs–GSH) nanoparticles and their covalent attachment to Zn monocarboxyphenoxy phthalocyanine (1) via amide bond formation. The photophysicochemical properties and photodynamic therapy (PDT) activity of the complex and its nanoconjugates were assessed. The conjugates afforded improved triplet and singlet oxygen quantum yield as well as PDT activity (except for 1-Au3Ag1NPs which afforded decreased activity) in comparison to complex 1.enAmide bondGlutathioneMelanomaNanoconjugatesSinglet quantum yieldZinc phthalocyanineArticleOluwole, D., Manoto, S. L., Malabi, R., Maphanga, C. P., Ombinda-Lemboumba, S., Mthunzi-Kufa, P., & Nyokong, T. (2018). Evaluation of the photophysicochemical properties and photodynamic therapy activity of nanoconjugates of zinc phthalocyanine linked to glutathione capped Au and Au3Ag1 nanoparticles. http://hdl.handle.net/10204/9912Oluwole, DA, Sello L Manoto, Rudzani Malabi, Charles P Maphanga, Saturnin Ombinda-Lemboumba, Patience Mthunzi-Kufa, and T Nyokong "Evaluation of the photophysicochemical properties and photodynamic therapy activity of nanoconjugates of zinc phthalocyanine linked to glutathione capped Au and Au3Ag1 nanoparticles." (2018) http://hdl.handle.net/10204/9912Oluwole D, Manoto SL, Malabi R, Maphanga CP, Ombinda-Lemboumba S, Mthunzi-Kufa P, et al. Evaluation of the photophysicochemical properties and photodynamic therapy activity of nanoconjugates of zinc phthalocyanine linked to glutathione capped Au and Au3Ag1 nanoparticles. 2018; http://hdl.handle.net/10204/9912.TY - Article AU - Oluwole, DA AU - Manoto, Sello L AU - Malabi, Rudzani AU - Maphanga, Charles P AU - Ombinda-Lemboumba, Saturnin AU - Mthunzi-Kufa, Patience AU - Nyokong, T AB - We report on the synthesis of glutathione capped gold (AuNPs–GSH) and gold–silver (Au3Ag1NPs–GSH) nanoparticles and their covalent attachment to Zn monocarboxyphenoxy phthalocyanine (1) via amide bond formation. The photophysicochemical properties and photodynamic therapy (PDT) activity of the complex and its nanoconjugates were assessed. The conjugates afforded improved triplet and singlet oxygen quantum yield as well as PDT activity (except for 1-Au3Ag1NPs which afforded decreased activity) in comparison to complex 1. DA - 2018-03 DB - ResearchSpace DP - CSIR KW - Amide bond KW - Glutathione KW - Melanoma KW - Nanoconjugates KW - Singlet quantum yield KW - Zinc phthalocyanine LK - https://researchspace.csir.co.za PY - 2018 SM - 0143-7208 T1 - Evaluation of the photophysicochemical properties and photodynamic therapy activity of nanoconjugates of zinc phthalocyanine linked to glutathione capped Au and Au3Ag1 nanoparticles TI - Evaluation of the photophysicochemical properties and photodynamic therapy activity of nanoconjugates of zinc phthalocyanine linked to glutathione capped Au and Au3Ag1 nanoparticles UR - http://hdl.handle.net/10204/9912 ER -