Manoto, Sello LThobakgale, Setumo LMalabi, Khorommbi PMaphanga, Charles POmbinda-Lemboumba, SaturninMthunzi-Kufa, Patience2018-01-042018-01-042017-10Manoto, S.L. et al. 2017. Therapeutic strategies to fight HIV-1 latency: progress and challenges. Biologia, vol. 72(10): 1101-11120006-3088DOI: 10.1515/biolog-2017-0131https://www.degruyter.com/view/j/biolog.2017.72.issue-10/biolog-2017-0131/biolog-2017-0131.xmlhttp://hdl.handle.net/10204/9930Copyright: 2017 Institute of Molecular Biology, Slovak Academy of Sciences. Due to copyright restrictions, the attached PDF file only contains the abstract of the full text item. For access to the full text item, please consult the publisher's website.The life-long persistence of human immunodeficiency virus type-1 (HIV-1) in latent reservoirs is a major hurdle in the eradication of HIV-1, even though highly active antiretroviral therapy (HAART) can be effective in reducing the plasma HIV-1 RNA to less than 50 copies per mL, which is below the detection limit of most clinical assays. In the latent reservoirs the provirus is integrated in the host genome but does not actively replicate and thus is not inhibited by HAART or recognized by the host immune system. There has been increasing scientific interest and investment into research towards HIV cure due to the challenges and limitation of life long treatment. The various strategies that have been developed aim to activate gene expression in HIV latent cells which might lead to the elimination of the virus by HAART or the immune system. In this review we discuss latency and therapeutic approaches that are being evaluated to eradicate HIV latently infected cells to overcome the burden of life long HAART. In addition, we explore the possibility of delivering HAART in latently infected cells using femtosecond laser pulses, a topic closely studied in our research.enHIVHighly active antiretroviral therapyLatencyFemtosecond laser pulsesArticleManoto, S. L., Thobakgale, S. L., Malabi, K. P., Maphanga, C. P., Ombinda-Lemboumba, S., & Mthunzi-Kufa, P. (2017). Therapeutic strategies to fight HIV-1 latency: progress and challenges. http://hdl.handle.net/10204/9930Manoto, Sello L, Setumo L Thobakgale, Khorommbi P Malabi, Charles P Maphanga, Saturnin Ombinda-Lemboumba, and Patience Mthunzi-Kufa "Therapeutic strategies to fight HIV-1 latency: progress and challenges." (2017) http://hdl.handle.net/10204/9930Manoto SL, Thobakgale SL, Malabi KP, Maphanga CP, Ombinda-Lemboumba S, Mthunzi-Kufa P. Therapeutic strategies to fight HIV-1 latency: progress and challenges. 2017; http://hdl.handle.net/10204/9930.TY - Article AU - Manoto, Sello L AU - Thobakgale, Setumo L AU - Malabi, Khorommbi P AU - Maphanga, Charles P AU - Ombinda-Lemboumba, Saturnin AU - Mthunzi-Kufa, Patience AB - The life-long persistence of human immunodeficiency virus type-1 (HIV-1) in latent reservoirs is a major hurdle in the eradication of HIV-1, even though highly active antiretroviral therapy (HAART) can be effective in reducing the plasma HIV-1 RNA to less than 50 copies per mL, which is below the detection limit of most clinical assays. In the latent reservoirs the provirus is integrated in the host genome but does not actively replicate and thus is not inhibited by HAART or recognized by the host immune system. There has been increasing scientific interest and investment into research towards HIV cure due to the challenges and limitation of life long treatment. The various strategies that have been developed aim to activate gene expression in HIV latent cells which might lead to the elimination of the virus by HAART or the immune system. In this review we discuss latency and therapeutic approaches that are being evaluated to eradicate HIV latently infected cells to overcome the burden of life long HAART. In addition, we explore the possibility of delivering HAART in latently infected cells using femtosecond laser pulses, a topic closely studied in our research. DA - 2017-10 DB - ResearchSpace DP - CSIR KW - HIV KW - Highly active antiretroviral therapy KW - Latency KW - Femtosecond laser pulses LK - https://researchspace.csir.co.za PY - 2017 SM - 0006-3088 T1 - Therapeutic strategies to fight HIV-1 latency: progress and challenges TI - Therapeutic strategies to fight HIV-1 latency: progress and challenges UR - http://hdl.handle.net/10204/9930 ER -