Van Heerden, FRHorak, RMMaharaj, VJVleggaar, RSenabe, JVGunning, PJ2007-06-292007-06-292007-04Van Heerden, FR et al. 2007. An appetite suppressant from Hoodia species. Tetrahedron Letters0040-4039http://hdl.handle.net/10204/765Copyright: 2007 Pergamon-Elsevier Science LtdTwo new pregnane glycosides were isolated by fractionation of the dried stems of Hoodia gordonii. Their structures were determined as 3beta-[beta-D-thevetopyranosyl-(1→4)-beta-D-cymaropyranosyl-(1→4)-beta-D-cymaropyranosyloxy]-12beta-tigloyloxy-14beta-hydroxypregn-5-en-20-one (1) and 3beta-[beta-D-cymaropyranosyl-(1→4)-beta-D-6-deoxy-3-O-methylallopyranosyl-(1→4)-beta-D-cymaropyranosyl-(1→4)-beta-D-cymaropyranosyloxy]-12beta-tigloyloxy-14beta-hydroxypregn-5-en-20-one (2) on the basis of spectroscopic studies and conversion to known compounds. Compounds 1 and 2 were also isolated from Hoodia pilifera. Compound 1 was tested for its appetite-suppressant properties in rats by oral gavage at 6.25 to 50 mg/kg and the results showed that all doses resulted in a decrease of food consumption over an eight day period and a body mass decrease when compared to the control sample receiving only the vehicle. In a comparative study against a fenfluramine control sample, compound 1 resulted in a reduction in food intake over the study period, with a concomitant overall decrease in body weight while fenfluramine resulted in a small decrease in food intake, but an increase in body weight (though less than control group) over the same period of time.enHoodia piliferaHoodia gordoniiApocynaceaeFenfluramineGhaapAppetite suppressantPregnane glycosideCymaroseThevetoseMethyl b-lilacinobioside12-O-tigloyldigipurpurogeninArticleVan Heerden, F., Horak, R., Maharaj, V., Vleggaar, R., Senabe, J., & Gunning, P. (2007). An appetite suppressant from Hoodia species. http://hdl.handle.net/10204/765Van Heerden, FR, RM Horak, VJ Maharaj, R Vleggaar, JV Senabe, and PJ Gunning "An appetite suppressant from Hoodia species." (2007) http://hdl.handle.net/10204/765Van Heerden F, Horak R, Maharaj V, Vleggaar R, Senabe J, Gunning P. An appetite suppressant from Hoodia species. 2007; http://hdl.handle.net/10204/765.TY - Article AU - Van Heerden, FR AU - Horak, RM AU - Maharaj, VJ AU - Vleggaar, R AU - Senabe, JV AU - Gunning, PJ AB - Two new pregnane glycosides were isolated by fractionation of the dried stems of Hoodia gordonii. Their structures were determined as 3beta-[beta-D-thevetopyranosyl-(1→4)-beta-D-cymaropyranosyl-(1→4)-beta-D-cymaropyranosyloxy]-12beta-tigloyloxy-14beta-hydroxypregn-5-en-20-one (1) and 3beta-[beta-D-cymaropyranosyl-(1→4)-beta-D-6-deoxy-3-O-methylallopyranosyl-(1→4)-beta-D-cymaropyranosyl-(1→4)-beta-D-cymaropyranosyloxy]-12beta-tigloyloxy-14beta-hydroxypregn-5-en-20-one (2) on the basis of spectroscopic studies and conversion to known compounds. Compounds 1 and 2 were also isolated from Hoodia pilifera. Compound 1 was tested for its appetite-suppressant properties in rats by oral gavage at 6.25 to 50 mg/kg and the results showed that all doses resulted in a decrease of food consumption over an eight day period and a body mass decrease when compared to the control sample receiving only the vehicle. In a comparative study against a fenfluramine control sample, compound 1 resulted in a reduction in food intake over the study period, with a concomitant overall decrease in body weight while fenfluramine resulted in a small decrease in food intake, but an increase in body weight (though less than control group) over the same period of time. DA - 2007-04 DB - ResearchSpace DP - CSIR KW - Hoodia pilifera KW - Hoodia gordonii KW - Apocynaceae KW - Fenfluramine KW - Ghaap KW - Appetite suppressant KW - Pregnane glycoside KW - Cymarose KW - Thevetose KW - Methyl b-lilacinobioside KW - 12-O-tigloyldigipurpurogenin LK - https://researchspace.csir.co.za PY - 2007 SM - 0040-4039 T1 - An appetite suppressant from Hoodia species TI - An appetite suppressant from Hoodia species UR - http://hdl.handle.net/10204/765 ER -