Chhiba, Varsha PBode, MMathiba, KBrady, D2015-02-092015-02-092014-06Chhiba, V, Bode, M, Mathiba, K and Brady, D. 2014. Enzymatic stereoselective synthesis of B-amino acids. In: Cascade Biocatalysis: Integrating Stereoselective and Environmentally Friendly Reactions. John Wiley & Sons: New York, United States, pp 297-3149783527335220http://onlinelibrary.wiley.com/doi/10.1002/9783527682492.ch14/summaryhttp://hdl.handle.net/10204/7859Copyright: John Wiley & Sons, New York, USA. Only Abstract is attached.The use of enzymes for the enantioselective synthesis of single enantiomer ß-subsituted compounds is of interest, as this structural motif occurs commonly in compounds of pharmaceutical importance, such as adrenergic agents, antidiabetics, antimicrobials, and as nonstandard amino acids in therapeutic peptides or peptidomimetics. Access to these compounds can be achieved through diverse synthetic routes with enantioselective steps catalyzed in different ways, including by means of nitrile hydrolysis. The selectivity of nitrile biocatalysts has been demonstrated on various nitrile-containing substrates. Enantioselectivity has been achieved using either nitrilases or nitrile hydratase-amidase pairs in a cascade reaction. Nitrile-hydrolysing Rhodococci have been applied in the synthesis of both ß(sup3)-amino and ß(sup2)-amino acids. These discoveries are broadening the biocatalytic toolbox available for the sysnthesis of single enantiomer ß-subsituted amino acids and amides.enß-amino acidPeptidomimeticsNitrile hydrataseNitrilaseKinetic resolutionAmidaseBook ChapterChhiba, V. P., Bode, M., Mathiba, K., & Brady, D. (2014). Enzymatic stereoselective synthesis of B-Amino acids., <i>Workflow;13783</i> Wiley. http://hdl.handle.net/10204/7859Chhiba, Varsha P, M Bode, K Mathiba, and D Brady. "Enzymatic stereoselective synthesis of B-amino acids" In <i>WORKFLOW;13783</i>, n.p.: Wiley. 2014. http://hdl.handle.net/10204/7859.Chhiba VP, Bode M, Mathiba K, Brady D. Enzymatic stereoselective synthesis of B-amino acids.. Workflow;13783. [place unknown]: Wiley; 2014. [cited yyyy month dd]. http://hdl.handle.net/10204/7859.TY - Book Chapter AU - Chhiba, Varsha P AU - Bode, M AU - Mathiba, K AU - Brady, D AB - The use of enzymes for the enantioselective synthesis of single enantiomer ß-subsituted compounds is of interest, as this structural motif occurs commonly in compounds of pharmaceutical importance, such as adrenergic agents, antidiabetics, antimicrobials, and as nonstandard amino acids in therapeutic peptides or peptidomimetics. Access to these compounds can be achieved through diverse synthetic routes with enantioselective steps catalyzed in different ways, including by means of nitrile hydrolysis. The selectivity of nitrile biocatalysts has been demonstrated on various nitrile-containing substrates. Enantioselectivity has been achieved using either nitrilases or nitrile hydratase-amidase pairs in a cascade reaction. Nitrile-hydrolysing Rhodococci have been applied in the synthesis of both ß(sup3)-amino and ß(sup2)-amino acids. These discoveries are broadening the biocatalytic toolbox available for the sysnthesis of single enantiomer ß-subsituted amino acids and amides. DA - 2014-06 DB - ResearchSpace DP - CSIR KW - ß-amino acid KW - Peptidomimetics KW - Nitrile hydratase KW - Nitrilase KW - Kinetic resolution KW - Amidase LK - https://researchspace.csir.co.za PY - 2014 SM - 9783527335220 T1 - Enzymatic stereoselective synthesis of B-amino acids TI - Enzymatic stereoselective synthesis of B-amino acids UR - http://hdl.handle.net/10204/7859 ER -