Becker, JVWMtwisha, LCrampton, BGStoychev, Stoyan HVan Brummelen, ACReeksting, SLouw, AIBirkholtz, LMMancama, Dalubuhle T2010-11-112010-11-112010-01Becker, JVW, Mtwisha, L, Crampton, BG et al. 2010. Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels. BMC Genomics, Vol. 11(235), pp 1-161471-2164http://hdl.handle.net/10204/4549Copyright: 2010 Becker et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly citedThis study details the malaria parasite's response to PfSpdSyn inhibition on the transcriptomic, proteomic and metabolic levels. The results corroborate and significantly expand previous functional genomics studies relating to polyamine depletion in this parasite. Moreover, they confirm the role of transcriptional regulation in P. falciparum, particularly in this pathway. The findings promote this essential pathway as a target for antimalarial chemotherapeutic intervention strategiesenPlasmodium falciparumPlasmodium falciparum spermidine synthasePfSpdSynAntimalarial drug resistanceMalariaHuman malariaGenomicsArticleBecker, J., Mtwisha, L., Crampton, B., Stoychev, S. H., Van Brummelen, A., Reeksting, S., ... Mancama, D. T. (2010). Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels. http://hdl.handle.net/10204/4549Becker, JVW, L Mtwisha, BG Crampton, Stoyan H Stoychev, AC Van Brummelen, S Reeksting, AI Louw, LM Birkholtz, and Dalubuhle T Mancama "Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels." (2010) http://hdl.handle.net/10204/4549Becker J, Mtwisha L, Crampton B, Stoychev SH, Van Brummelen A, Reeksting S, et al. Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels. 2010; http://hdl.handle.net/10204/4549.TY - Article AU - Becker, JVW AU - Mtwisha, L AU - Crampton, BG AU - Stoychev, Stoyan H AU - Van Brummelen, AC AU - Reeksting, S AU - Louw, AI AU - Birkholtz, LM AU - Mancama, Dalubuhle T AB - This study details the malaria parasite's response to PfSpdSyn inhibition on the transcriptomic, proteomic and metabolic levels. The results corroborate and significantly expand previous functional genomics studies relating to polyamine depletion in this parasite. Moreover, they confirm the role of transcriptional regulation in P. falciparum, particularly in this pathway. The findings promote this essential pathway as a target for antimalarial chemotherapeutic intervention strategies DA - 2010-01 DB - ResearchSpace DP - CSIR KW - Plasmodium falciparum KW - Plasmodium falciparum spermidine synthase KW - PfSpdSyn KW - Antimalarial drug resistance KW - Malaria KW - Human malaria KW - Genomics LK - https://researchspace.csir.co.za PY - 2010 SM - 1471-2164 T1 - Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels TI - Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels UR - http://hdl.handle.net/10204/4549 ER -