Karsten, AESmit, Jacoba E2012-03-222012-03-222012-03Karsten, AE and Smit, JE. 2012. Modelling and verification of melanin concentration on human skin type. Photochemistry and Photobiology, vol. 88(2), pp 469-4740031-8655http://onlinelibrary.wiley.com/doi/10.1111/j.1751-1097.2011.01044.x/pdfhttp://hdl.handle.net/10204/5666Copyright: 2011 The American Society of Photobiology. This is the pre-print version of the work. The definitive version is published in Photochemistry and Photobiology, vol. 88(2), pp 469-474Lasers are used in the minimalistic or noninvasive diagnosis and treatment of skin disorders. Less laser light reaches the deeper skin layers in dark skin types, due to its higher epidermal melanin concentration compared with lighter skin. Laser–tissue interaction modeling software can correct for this by adapting the dose applied to the skin. This necessitates an easy and reliable method to determine the skin’s type. Noninvasive measurement of the skin’s melanin content is the best method. However, access to samples of all skin types is often limited and skin-like phantoms are used instead. This study’s objective is to compare experimentally measured absorption features of liquid skin-like phantoms representing Skin Types I–VI with a realistic skin computational model component of ASAP®. Sample UV–VIS transmittance spectra were measured from 370 to 900 nm and compared with simulated results from ASAP® using the same optical parameters. Results indicated nonmonotonic absorption features towards shorter wavelengths, which may allow for more accurate ways of determining melanin concentration and expected absorption through the epidermal layer. This suggests possible use in representing optical characteristics of real skin. However, a more comprehensive model and phantoms are necessary to account for the effects of sun exposure.enSun exposure effectsSkin disordersLaser skin treatmentMelanin concentration 1Laser lightsMelaninSkin typeComputational modellingSkin-like phantomsSkin-like phantomsSun exposureMelanin concentrationAbsorption spectroscopySkin modelsLiquid skin-like phantomsNon-monotonic absorption featuresArticleKarsten, A., & Smit, J. E. (2012). Modelling and verification of melanin concentration on human skin type. http://hdl.handle.net/10204/5666Karsten, AE, and Jacoba E Smit "Modelling and verification of melanin concentration on human skin type." (2012) http://hdl.handle.net/10204/5666Karsten A, Smit JE. Modelling and verification of melanin concentration on human skin type. 2012; http://hdl.handle.net/10204/5666.TY - Article AU - Karsten, AE AU - Smit, Jacoba E AB - Lasers are used in the minimalistic or noninvasive diagnosis and treatment of skin disorders. Less laser light reaches the deeper skin layers in dark skin types, due to its higher epidermal melanin concentration compared with lighter skin. Laser–tissue interaction modeling software can correct for this by adapting the dose applied to the skin. This necessitates an easy and reliable method to determine the skin’s type. Noninvasive measurement of the skin’s melanin content is the best method. However, access to samples of all skin types is often limited and skin-like phantoms are used instead. This study’s objective is to compare experimentally measured absorption features of liquid skin-like phantoms representing Skin Types I–VI with a realistic skin computational model component of ASAP®. Sample UV–VIS transmittance spectra were measured from 370 to 900 nm and compared with simulated results from ASAP® using the same optical parameters. Results indicated nonmonotonic absorption features towards shorter wavelengths, which may allow for more accurate ways of determining melanin concentration and expected absorption through the epidermal layer. This suggests possible use in representing optical characteristics of real skin. However, a more comprehensive model and phantoms are necessary to account for the effects of sun exposure. DA - 2012-03 DB - ResearchSpace DP - CSIR KW - Sun exposure effects KW - Skin disorders KW - Laser skin treatment KW - Melanin concentration 1 KW - Laser lights KW - Melanin KW - Skin type KW - Computational modelling KW - Skin-like phantoms KW - Skin-like phantoms KW - Sun exposure KW - Melanin concentration KW - Absorption spectroscopy KW - Skin models KW - Liquid skin-like phantoms KW - Non-monotonic absorption features LK - https://researchspace.csir.co.za PY - 2012 SM - 0031-8655 T1 - Modelling and verification of melanin concentration on human skin type TI - Modelling and verification of melanin concentration on human skin type UR - http://hdl.handle.net/10204/5666 ER -