Vahdat, MMHemmati, FGhorbani, ARutkowska, Daria AAfsharifar, AEskandari, MHRezaei, NNiazi, A2022-02-272022-02-272021-03Vahdat, M., Hemmati, F., Ghorbani, A., Rutkowska, D., Afsharifar, A., Eskandari, M., Rezaei, N. & Niazi, A. et al. 2021. Hepatitis B core-based virus-like particles: A platform for vaccine development in plants. <i>Biotechnology Reports, 29.</i> http://hdl.handle.net/10204/122972215-017Xhttps://doi.org/10.1016/j.btre.2021.e00605http://hdl.handle.net/10204/12297Virus-like particles (VLPs) are a class of structures formed by the self-assembly of viral capsid protein subunits and contain no infective viral genetic material. The Hepatitis B core (HBc) antigen is capable of assembling into VLPs that can elicit strong immune responses and has been licensed as a commercial vaccine against Hepatitis B. The HBc VLPs have also been employed as a platform for the presentation of foreign epitopes to the immune system and have been used to develop vaccines against, for example, influenza A and Foot-and-mouth disease. Plant expression systems are rapid, scalable and safe, and are capable of providing correct post-translational modifications and reducing upstream production costs. The production of HBc-based virus-like particles in plants would thus greatly increase the efficiency of vaccine production. This review investigates the application of plant-based HBc VLP as a platform for vaccine production.AbstractenHepatitis B corePlant expression systemVirus-like particleVLP-based vaccineArticleVahdat, M., Hemmati, F., Ghorbani, A., Rutkowska, D., Afsharifar, A., Eskandari, M., ... Niazi, A. (2021). Hepatitis B core-based virus-like particles: A platform for vaccine development in plants. <i>Biotechnology Reports, 29</i>, http://hdl.handle.net/10204/12297Vahdat, MM, F Hemmati, A Ghorbani, Daria Rutkowska, A Afsharifar, MH Eskandari, N Rezaei, and A Niazi "Hepatitis B core-based virus-like particles: A platform for vaccine development in plants." <i>Biotechnology Reports, 29</i> (2021) http://hdl.handle.net/10204/12297Vahdat M, Hemmati F, Ghorbani A, Rutkowska D, Afsharifar A, Eskandari M, et al. Hepatitis B core-based virus-like particles: A platform for vaccine development in plants. Biotechnology Reports, 29. 2021; http://hdl.handle.net/10204/12297.TY - Article AU - Vahdat, MM AU - Hemmati, F AU - Ghorbani, A AU - Rutkowska, Daria AU - Afsharifar, A AU - Eskandari, MH AU - Rezaei, N AU - Niazi, A AB - Virus-like particles (VLPs) are a class of structures formed by the self-assembly of viral capsid protein subunits and contain no infective viral genetic material. The Hepatitis B core (HBc) antigen is capable of assembling into VLPs that can elicit strong immune responses and has been licensed as a commercial vaccine against Hepatitis B. The HBc VLPs have also been employed as a platform for the presentation of foreign epitopes to the immune system and have been used to develop vaccines against, for example, influenza A and Foot-and-mouth disease. Plant expression systems are rapid, scalable and safe, and are capable of providing correct post-translational modifications and reducing upstream production costs. The production of HBc-based virus-like particles in plants would thus greatly increase the efficiency of vaccine production. This review investigates the application of plant-based HBc VLP as a platform for vaccine production. DA - 2021-03 DB - ResearchSpace DP - CSIR J1 - Biotechnology Reports, 29 KW - Hepatitis B core KW - Plant expression system KW - Virus-like particle KW - VLP-based vaccine LK - https://researchspace.csir.co.za PY - 2021 SM - 2215-017X T1 - Hepatitis B core-based virus-like particles: A platform for vaccine development in plants TI - Hepatitis B core-based virus-like particles: A platform for vaccine development in plants UR - http://hdl.handle.net/10204/12297 ER -25044