Assessing a sustainable manufacturing route to lapatinib

Stark, RTRye, DRNewton, OJDeadman, BJMiller, PWPanayides, Jenny-LeeRiley, Darren LHelldardt, KHii, KK2023-03-172023-03-172022-08Stark, R., Rye, D., Newton, O., Deadman, B., Miller, P., Panayides, J., Riley, D.L. & Helldardt, K. et al. 2022. Assessing a sustainable manufacturing route to lapatinib. Reaction Chemistry & Engineering, 7. http://hdl.handle.net/10204/126822058-9883DOI https://doi.org/10.1039/D2RE00267Ahttp://hdl.handle.net/10204/12682A synthetic route to an anti-cancer drug, lapatinib, was devised to support the development of a sustainable manufacturing process in South Africa. Quantitative metrics were employed to evaluate the sustainability of the key steps of the reaction.FulltextenBreast cancerRisk factorsBRCA1 genesBRCA2 genesAssessing a sustainable manufacturing route to lapatinibArticleStark, R., Rye, D., Newton, O., Deadman, B., Miller, P., Panayides, J., ... Hii, K. (2022). Assessing a sustainable manufacturing route to lapatinib. Reaction Chemistry & Engineering, 7, http://hdl.handle.net/10204/12682Stark, RT, DR Rye, OJ Newton, BJ Deadman, PW Miller, Jenny-Lee Panayides, Darren L Riley, K Helldardt, and KK Hii "Assessing a sustainable manufacturing route to lapatinib." Reaction Chemistry & Engineering, 7 (2022) http://hdl.handle.net/10204/12682Stark R, Rye D, Newton O, Deadman B, Miller P, Panayides J, et al. Assessing a sustainable manufacturing route to lapatinib. Reaction Chemistry & Engineering, 7. 2022; http://hdl.handle.net/10204/12682.TY - Article AU - Stark, RT AU - Rye, DR AU - Newton, OJ AU - Deadman, BJ AU - Miller, PW AU - Panayides, Jenny-Lee AU - Riley, Darren L AU - Helldardt, K AU - Hii, KK AB - A synthetic route to an anti-cancer drug, lapatinib, was devised to support the development of a sustainable manufacturing process in South Africa. Quantitative metrics were employed to evaluate the sustainability of the key steps of the reaction. DA - 2022-08 DB - ResearchSpace DP - CSIR J1 - Reaction Chemistry & Engineering, 7 KW - Breast cancer KW - Risk factors KW - BRCA1 genes KW - BRCA2 genes LK - https://researchspace.csir.co.za PY - 2022 SM - 2058-9883 T1 - Assessing a sustainable manufacturing route to lapatinib TI - Assessing a sustainable manufacturing route to lapatinib UR - http://hdl.handle.net/10204/12682 ER -26614