Mzondo, BuntubonkeDlamini, NomusaMalan, FPLabuschagne, Philip WBovilla, VRMadhunapantula, SVMaharaj, V2021-10-042021-10-042021-06Mzondo, B., Dlamini, N., Malan, F., Labuschagne, P.W., Bovilla, V., Madhunapantula, S. & Maharaj, V. 2021. Dammarane-type triterpenoids with anti-cancer activity from the leaves of Cleome gynandra. <i>Phytochemistry Letters, 43.</i> http://hdl.handle.net/10204/121191874-39001876-7486https://doi.org/10.1016/j.phytol.2021.03.001http://hdl.handle.net/10204/12119Three dammarane-type triterpernoids including two new ones, cleogynones A and B (1 and 2), were isolated from the leaves of Cleome gynandra. The structures of the new triterpenoids were elucidated by spectroscopic data analysis and confirmed by single crystal X-ray crystallography. All three compounds showed moderate cytotoxicity against breast cancer (MDA-MB-468), cleogynone B (2) and compound (3) further showed cytotoxicity against colorectal cancer (HCT-116 & HCT-15). Cleogynone B was also moderately active against lung cancer (A549).AbstractenCleome gynandraColor ectal cancerDamm ar ane triterpernoidsBreast cancerLung cancerArticleMzondo, B., Dlamini, N., Malan, F., Labuschagne, P. W., Bovilla, V., Madhunapantula, S., & Maharaj, V. (2021). Dammarane-type triterpenoids with anti-cancer activity from the leaves of Cleome gynandra. <i>Phytochemistry Letters, 43</i>, http://hdl.handle.net/10204/12119Mzondo, Buntubonke, Nomusa Dlamini, FP Malan, Philip W Labuschagne, VR Bovilla, SV Madhunapantula, and V Maharaj "Dammarane-type triterpenoids with anti-cancer activity from the leaves of Cleome gynandra." <i>Phytochemistry Letters, 43</i> (2021) http://hdl.handle.net/10204/12119Mzondo B, Dlamini N, Malan F, Labuschagne PW, Bovilla V, Madhunapantula S, et al. Dammarane-type triterpenoids with anti-cancer activity from the leaves of Cleome gynandra. Phytochemistry Letters, 43. 2021; http://hdl.handle.net/10204/12119.TY - Article AU - Mzondo, Buntubonke AU - Dlamini, Nomusa AU - Malan, FP AU - Labuschagne, Philip W AU - Bovilla, VR AU - Madhunapantula, SV AU - Maharaj, V AB - Three dammarane-type triterpernoids including two new ones, cleogynones A and B (1 and 2), were isolated from the leaves of Cleome gynandra. The structures of the new triterpenoids were elucidated by spectroscopic data analysis and confirmed by single crystal X-ray crystallography. All three compounds showed moderate cytotoxicity against breast cancer (MDA-MB-468), cleogynone B (2) and compound (3) further showed cytotoxicity against colorectal cancer (HCT-116 & HCT-15). Cleogynone B was also moderately active against lung cancer (A549). DA - 2021-06 DB - ResearchSpace DP - CSIR J1 - Phytochemistry Letters, 43 KW - Cleome gynandra KW - Color ectal cancer KW - Damm ar ane triterpernoids KW - Breast cancer KW - Lung cancer LK - https://researchspace.csir.co.za PY - 2021 SM - 1874-3900 SM - 1876-7486 T1 - Dammarane-type triterpenoids with anti-cancer activity from the leaves of Cleome gynandra TI - Dammarane-type triterpenoids with anti-cancer activity from the leaves of Cleome gynandra UR - http://hdl.handle.net/10204/12119 ER -24921