Alexandre, Kabamba BMufhandu, Hazel TLondon, GMChakauya, EKhati, M2018-01-152018-01-152016-10Alexandre, K.B. et al. 2016. Progress and perspectives on HIV-1 microbicide development. Virology, vol. 497: 69-800042-6822http://www.sciencedirect.com/science/article/pii/S0042682216301714https://doi.org/10.1016/j.virol.2016.07.004http://hdl.handle.net/10204/9952This is an Open Access article, published under a Creative Commons license.The majority of HIV-1 infections occur via sexual intercourse. Women are the most affected by the epidemic, particularly in developing countries, due to their socio-economic dependence on men and the fact that they are often victims of gender based sexual violence. Despite significant efforts that resulted in the reduction of infection rates in some countries, there is still need for effective prevention methods against the virus. One of these methods for preventing sexual transmission in women is the use of microbicides. In this review we provide a summary of the progress made toward the discovery of affordable and effective HIV-1 microbicides and suggest future directions. We show that there is a wide range of compounds that have been proposed as potential microbicides. Although most of them have so far failed to show protection in humans, there are many promising ones currently in pre-clinical studies and in clinical trials.enHIV-1 infectionsMicrobicidesSexual transmissionHIV preventionArticleAlexandre, K. B., Mufhandu, H. T., London, G., Chakauya, E., & Khati, M. (2016). Progress and perspectives on HIV-1 microbicide development. http://hdl.handle.net/10204/9952Alexandre, Kabamba B, Hazel T Mufhandu, GM London, E Chakauya, and M Khati "Progress and perspectives on HIV-1 microbicide development." (2016) http://hdl.handle.net/10204/9952Alexandre KB, Mufhandu HT, London G, Chakauya E, Khati M. Progress and perspectives on HIV-1 microbicide development. 2016; http://hdl.handle.net/10204/9952.TY - Article AU - Alexandre, Kabamba B AU - Mufhandu, Hazel T AU - London, GM AU - Chakauya, E AU - Khati, M AB - The majority of HIV-1 infections occur via sexual intercourse. Women are the most affected by the epidemic, particularly in developing countries, due to their socio-economic dependence on men and the fact that they are often victims of gender based sexual violence. Despite significant efforts that resulted in the reduction of infection rates in some countries, there is still need for effective prevention methods against the virus. One of these methods for preventing sexual transmission in women is the use of microbicides. In this review we provide a summary of the progress made toward the discovery of affordable and effective HIV-1 microbicides and suggest future directions. We show that there is a wide range of compounds that have been proposed as potential microbicides. Although most of them have so far failed to show protection in humans, there are many promising ones currently in pre-clinical studies and in clinical trials. DA - 2016-10 DB - ResearchSpace DP - CSIR KW - HIV-1 infections KW - Microbicides KW - Sexual transmission KW - HIV prevention LK - https://researchspace.csir.co.za PY - 2016 SM - 0042-6822 T1 - Progress and perspectives on HIV-1 microbicide development TI - Progress and perspectives on HIV-1 microbicide development UR - http://hdl.handle.net/10204/9952 ER -