Chetty, ASSeynberg, TJMoolman, FSNilen, RWNJoubert, AMRichter, PW2008-12-082008-12-082006-02Chetty, AS, Seynberg, TJ, Moolman, FS et al. 2006. Surface coated polyurethane with improved bioactivity and cytocompatability. CSIR Research and Innovation Conference: 1st CSIR Biennial Conference, CSIR International Convention Centre Pretoria, 26-27 February 2006, pp1http://hdl.handle.net/10204/2677CSIR Research and Innovation Conference: 1st CSIR Biennial Conference, CSIR International Convention Centre Pretoria, 26-27 February 2006Polyurethane (PU) may be suitable for various implant applications; however, it lacks bioactivity. Bioactivity allows for direct tissue attachment at the bio- interface, enabling implant fixation while preventing fibrous encapsulation. To impart bioactivity, PU was coated with a layer of hydroxyapatite (HA) by a solvent- compression method. Bioactivity of the HA- coated PU substrates was demonstrated by incubation in simulated body fluid (SBF) for up to nine days. Using crystal violet DNA staining and MTT (3- [4,5 dimethylthiazol- 2-yl]-2,5-diphenyl tetrazolium bromide) assay for determining the cell number and cell metabolic activity respectively, cytocompatibility of the HA-coated PU substrates was demonstrated towards a number of cell lines. The HA-coated PU substrates prepared in this study could find application where non- resorbable biomaterials are required, including cartilage replacement, maxillofacial implants, ID tags and biosensorsenBiomaterialsPolyurethaneHydroxyapatiteepCytocompatibilityConference PresentationChetty, A., Seynberg, T., Moolman, F., Nilen, R., Joubert, A., & Richter, P. (2006). Surface coated polyurethane with improved bioactivity and cytocompatability. http://hdl.handle.net/10204/2677Chetty, AS, TJ Seynberg, FS Moolman, RWN Nilen, AM Joubert, and PW Richter. "Surface coated polyurethane with improved bioactivity and cytocompatability." (2006): http://hdl.handle.net/10204/2677Chetty A, Seynberg T, Moolman F, Nilen R, Joubert A, Richter P, Surface coated polyurethane with improved bioactivity and cytocompatability; 2006. http://hdl.handle.net/10204/2677 .TY - Conference Presentation AU - Chetty, AS AU - Seynberg, TJ AU - Moolman, FS AU - Nilen, RWN AU - Joubert, AM AU - Richter, PW AB - Polyurethane (PU) may be suitable for various implant applications; however, it lacks bioactivity. Bioactivity allows for direct tissue attachment at the bio- interface, enabling implant fixation while preventing fibrous encapsulation. To impart bioactivity, PU was coated with a layer of hydroxyapatite (HA) by a solvent- compression method. Bioactivity of the HA- coated PU substrates was demonstrated by incubation in simulated body fluid (SBF) for up to nine days. Using crystal violet DNA staining and MTT (3- [4,5 dimethylthiazol- 2-yl]-2,5-diphenyl tetrazolium bromide) assay for determining the cell number and cell metabolic activity respectively, cytocompatibility of the HA-coated PU substrates was demonstrated towards a number of cell lines. The HA-coated PU substrates prepared in this study could find application where non- resorbable biomaterials are required, including cartilage replacement, maxillofacial implants, ID tags and biosensors DA - 2006-02 DB - ResearchSpace DP - CSIR KW - Biomaterials KW - Polyurethane KW - Hydroxyapatiteep KW - Cytocompatibility LK - https://researchspace.csir.co.za PY - 2006 T1 - Surface coated polyurethane with improved bioactivity and cytocompatability TI - Surface coated polyurethane with improved bioactivity and cytocompatability UR - http://hdl.handle.net/10204/2677 ER -