Becker, JMtwisha, LCrampton, BGStoychev, Stoyan HVan Brummelen, ALouw, ABirkholtz, LMancama, Dalubuhle T2010-10-112010-10-112009-03Becker, J, Mtwisha, L, Crampton, BG. 2009. Inhibition of Plasmodium falciparum spermidine synthase indicates unique perturbation-specific effects in the transcriptome and proteome. Drug Discovery for Protozoan Parasites Conference. Beaver Run, Colorado, USA, 22 - 26 March 2009, pp1http://hdl.handle.net/10204/4468Drug Discovery for Protozoan Parasites Conference. Beaver Run, Colorado, USA, 22 - 26 March 2009Antiplasmodial drug discovery efforts are hampered by the lack of an extensive set of novel, validated drug targets. A requirement of these targets (or the pathways in which they function) is that they prove essential for parasite survival. The polyamine biosynthetic pathway, responsible for the metabolism of highly abundant amines crucial for parasite growth, proliferation and differentiation, is currently under investigation as an antimalarial target. In order to further evaluate polyamine depletion as possible antimalarial intervention, the consequences of inhibiting Plasmodium falciparum spermidine synthase was examined on a transcriptomic and proteomic level.enPlasmodium falciparumAntimalarialsDrug targetsDrug discoveryProtozoan parasitesConference PresentationBecker, J., Mtwisha, L., Crampton, B., Stoychev, S. H., Van Brummelen, A., Louw, A., ... Mancama, D. T. (2009). Inhibition of Plasmodium falciparum spermidine synthase indicates unique perturbation-specific effects in the transcriptome and proteome. http://hdl.handle.net/10204/4468Becker, J, L Mtwisha, BG Crampton, Stoyan H Stoychev, A Van Brummelen, A Louw, L Birkholtz, and Dalubuhle T Mancama. "Inhibition of Plasmodium falciparum spermidine synthase indicates unique perturbation-specific effects in the transcriptome and proteome." (2009): http://hdl.handle.net/10204/4468Becker J, Mtwisha L, Crampton B, Stoychev SH, Van Brummelen A, Louw A, et al, Inhibition of Plasmodium falciparum spermidine synthase indicates unique perturbation-specific effects in the transcriptome and proteome; 2009. http://hdl.handle.net/10204/4468 .TY - Conference Presentation AU - Becker, J AU - Mtwisha, L AU - Crampton, BG AU - Stoychev, Stoyan H AU - Van Brummelen, A AU - Louw, A AU - Birkholtz, L AU - Mancama, Dalubuhle T AB - Antiplasmodial drug discovery efforts are hampered by the lack of an extensive set of novel, validated drug targets. A requirement of these targets (or the pathways in which they function) is that they prove essential for parasite survival. The polyamine biosynthetic pathway, responsible for the metabolism of highly abundant amines crucial for parasite growth, proliferation and differentiation, is currently under investigation as an antimalarial target. In order to further evaluate polyamine depletion as possible antimalarial intervention, the consequences of inhibiting Plasmodium falciparum spermidine synthase was examined on a transcriptomic and proteomic level. DA - 2009-03 DB - ResearchSpace DP - CSIR KW - Plasmodium falciparum KW - Antimalarials KW - Drug targets KW - Drug discovery KW - Protozoan parasites LK - https://researchspace.csir.co.za PY - 2009 T1 - Inhibition of Plasmodium falciparum spermidine synthase indicates unique perturbation-specific effects in the transcriptome and proteome TI - Inhibition of Plasmodium falciparum spermidine synthase indicates unique perturbation-specific effects in the transcriptome and proteome UR - http://hdl.handle.net/10204/4468 ER -