Gonyela, OdwaPeter, Xolani KDewar, JBVan der Westhuysen, Christiaan WSteenkamp, PaulFouché, Gerda2020-07-272020-07-272019-08Gonyela, O. et al. 2019. Cycloartanol and Sutherlandioside C peracetate from Sutherlandia frutescens and their immune potentiating effects. Natural Product Research, pp. 91478-64191478-6427https://www.tandfonline.com/doi/full/10.1080/14786419.2019.1648457https://doi.org/10.1080/14786419.2019.1648457http://hdl.handle.net/10204/11516Copyright: 2019 Taylor & Francis. Due to copyright restrictions, the attached PDF file only contains the abstract of the full text item. For access to the full text item, please consult the publisher's website. The definitive version of the work is published in Natural Product Research, pp. 9A novel cycloartanol (1) and an acylated Sutherlandioside D (2) together with two known cycloartane derivatives, Sutherlandioside B (3) and Sutherlandioside A (4), were isolated from the aerial parts of Sutherlandia frutescens. The structures of these compounds were established by a combination of 1- and 2-D NMR techniques and further confirmed by high resolution ToF mass spectrometry (HRToFMS). Preliminary biological studies were also conducted to assess the activity of different plant extracts, fractions and compounds on cytokine expression. Compounds 1 and 2 prompted an increase in IL-6 expression while compound 4 showed a reduced IL-6 expression compared to the controls. Compound 1 is an effective suppressor of IL-10 expression. The plant compounds inhibited the expression of the two cytokines, IL-10 and TNFa. The results of the assays suggested that some components in the plant extract influence the immune system by suppressing the expression of IL-6, IL-10 and TNFa.en-USSutherlandia frutescens (L) R. Br (Fabaceae)ArticleGonyela, O., Peter, X. K., Dewar, J., Van der Westhuysen, C. W., Steenkamp, P., & Fouché, G. (2019). Cycloartanol and Sutherlandioside C peracetate from Sutherlandia frutescens and their immune potentiating effects. http://hdl.handle.net/10204/11516Gonyela, Odwa, Xolani K Peter, JB Dewar, Christiaan W Van der Westhuysen, Paul Steenkamp, and Gerda Fouché "Cycloartanol and Sutherlandioside C peracetate from Sutherlandia frutescens and their immune potentiating effects." (2019) http://hdl.handle.net/10204/11516Gonyela O, Peter XK, Dewar J, Van der Westhuysen CW, Steenkamp P, Fouché G. Cycloartanol and Sutherlandioside C peracetate from Sutherlandia frutescens and their immune potentiating effects. 2019; http://hdl.handle.net/10204/11516.TY - Article AU - Gonyela, Odwa AU - Peter, Xolani K AU - Dewar, JB AU - Van der Westhuysen, Christiaan W AU - Steenkamp, Paul AU - Fouché, Gerda AB - A novel cycloartanol (1) and an acylated Sutherlandioside D (2) together with two known cycloartane derivatives, Sutherlandioside B (3) and Sutherlandioside A (4), were isolated from the aerial parts of Sutherlandia frutescens. The structures of these compounds were established by a combination of 1- and 2-D NMR techniques and further confirmed by high resolution ToF mass spectrometry (HRToFMS). Preliminary biological studies were also conducted to assess the activity of different plant extracts, fractions and compounds on cytokine expression. Compounds 1 and 2 prompted an increase in IL-6 expression while compound 4 showed a reduced IL-6 expression compared to the controls. Compound 1 is an effective suppressor of IL-10 expression. The plant compounds inhibited the expression of the two cytokines, IL-10 and TNFa. The results of the assays suggested that some components in the plant extract influence the immune system by suppressing the expression of IL-6, IL-10 and TNFa. DA - 2019-08 DB - ResearchSpace DP - CSIR KW - Sutherlandia frutescens (L) R. Br (Fabaceae) LK - https://researchspace.csir.co.za PY - 2019 SM - 1478-6419 SM - 1478-6427 T1 - Cycloartanol and Sutherlandioside C peracetate from Sutherlandia frutescens and their immune potentiating effects TI - Cycloartanol and Sutherlandioside C peracetate from Sutherlandia frutescens and their immune potentiating effects UR - http://hdl.handle.net/10204/11516 ER -