Mangisa, MTembu, VJFouché, GerdaNthambeleni, RudzaniPeter, Xolani KLangat, MK2018-09-182018-09-182018-05Mangisa, M. et al. 2018. Ent-abietane diterpenoids from Suregada zanzibariensis Baill. (Euphorbiaceae), their cytotoxic and anticancer properties. Natural Product Research, vol. 9: 1-81478-64191478-6427https://doi.org/10.1080/14786419.2018.1470628https://www.tandfonline.com/doi/full/10.1080/14786419.2018.1470628http://hdl.handle.net/10204/10406© 2018 Informa UK Limited, trading as Taylor & Francis Group. Due to copyright restrictions, the attached PDF file only contains the abstract of the full text item. For access to the full text item, please consult the publisher's website.The stem bark extract of Suregada zanzibariensis afforded a previously undescribed ent-abietane diterpenoid trivially named mangiolide (1) and a known jolkinolide B (2) via anticancer bioassay-guided fractionation. The CH(sub)2Cl(sub)2:MeOH extract of S. zanzibariensis was initially analysed for its anticancer properties against three cancer cell lines, renal (TK10), melanoma (UACC62), and breast (MCF7) and was found to be potent at low µg/mL ranges. Compound 1, 6a-acetoxy-14-ketoent-abieta-7(8),13(15)-diene-16,12-olide (mangiolide) inhibited the growth of renal (TK10) with a GI5(sub)50 of 0.02 µg/mL; a GI(sub)50 of 0.03 µg/mL for melanoma (UACC62) and a GI(sub)50 of 0.05 µg/mL for breast (MCF7) cancer cell lines. Compound 2, 8,13-diepoxy-13,15-ent-abietene-16,12-olide (jolkinolide B) inhibited the growth (GI(sub)50) of the cell lines at 3.31 µg/ mL for renal (TK10), 0.94 µg/mL for melanoma (UACC62) and 2.99 µg/ mL for the breast (MCF7). The structures were established on the basis of their spectroscopic analysis and the absolute stereostructures assigned using electronic circular dichroism (ECD).enCytotoxicityCancer cell linesEnt-abietane diterpenoid lactoneSuregada zanzibariensisEuphorbiaceaeArticleMangisa, M., Tembu, V., Fouché, G., Nthambeleni, R., Peter, X. K., & Langat, M. (2018). Ent-abietane diterpenoids from Suregada zanzibariensis Baill. (Euphorbiaceae), their cytotoxic and anticancer properties. http://hdl.handle.net/10204/10406Mangisa, M, VJ Tembu, Gerda Fouché, Rudzani Nthambeleni, Xolani K Peter, and MK Langat "Ent-abietane diterpenoids from Suregada zanzibariensis Baill. (Euphorbiaceae), their cytotoxic and anticancer properties." (2018) http://hdl.handle.net/10204/10406Mangisa M, Tembu V, Fouché G, Nthambeleni R, Peter XK, Langat M. Ent-abietane diterpenoids from Suregada zanzibariensis Baill. (Euphorbiaceae), their cytotoxic and anticancer properties. 2018; http://hdl.handle.net/10204/10406.TY - Article AU - Mangisa, M AU - Tembu, VJ AU - Fouché, Gerda AU - Nthambeleni, Rudzani AU - Peter, Xolani K AU - Langat, MK AB - The stem bark extract of Suregada zanzibariensis afforded a previously undescribed ent-abietane diterpenoid trivially named mangiolide (1) and a known jolkinolide B (2) via anticancer bioassay-guided fractionation. The CH(sub)2Cl(sub)2:MeOH extract of S. zanzibariensis was initially analysed for its anticancer properties against three cancer cell lines, renal (TK10), melanoma (UACC62), and breast (MCF7) and was found to be potent at low µg/mL ranges. Compound 1, 6a-acetoxy-14-ketoent-abieta-7(8),13(15)-diene-16,12-olide (mangiolide) inhibited the growth of renal (TK10) with a GI5(sub)50 of 0.02 µg/mL; a GI(sub)50 of 0.03 µg/mL for melanoma (UACC62) and a GI(sub)50 of 0.05 µg/mL for breast (MCF7) cancer cell lines. Compound 2, 8,13-diepoxy-13,15-ent-abietene-16,12-olide (jolkinolide B) inhibited the growth (GI(sub)50) of the cell lines at 3.31 µg/ mL for renal (TK10), 0.94 µg/mL for melanoma (UACC62) and 2.99 µg/ mL for the breast (MCF7). The structures were established on the basis of their spectroscopic analysis and the absolute stereostructures assigned using electronic circular dichroism (ECD). DA - 2018-05 DB - ResearchSpace DP - CSIR KW - Cytotoxicity KW - Cancer cell lines KW - Ent-abietane diterpenoid lactone KW - Suregada zanzibariensis KW - Euphorbiaceae LK - https://researchspace.csir.co.za PY - 2018 SM - 1478-6419 SM - 1478-6427 T1 - Ent-abietane diterpenoids from Suregada zanzibariensis Baill. (Euphorbiaceae), their cytotoxic and anticancer properties TI - Ent-abietane diterpenoids from Suregada zanzibariensis Baill. (Euphorbiaceae), their cytotoxic and anticancer properties UR - http://hdl.handle.net/10204/10406 ER -