Manoto, Sello L2020-01-312020-01-312020-01Manoto, S.L. 2020. Editorial commentary: Is medical ozone therapy beneficial in the treatment of knee osteoarthritis? Arthroscopy: The Journal of Arthroscopic & Related Surgery, V36(1), pp 287-2880749-80631526-3231https://www.meta.org/papers/editorial-commentary-is-medical-ozone-therapy/31864590https://www.ncbi.nlm.nih.gov/pubmed/31864590DOI: 10.1016/j.arthro.2019.09.036http://hdl.handle.net/10204/11289Copyright: 2020 Elsevier Inc. Due to copyright restrictions, the attached PDF file only contains the abstract of the full text item. For access to the full text item, kindly consult the publisher's website.Osteoarthritis is a degenerative joint disease that is difficult to manage and a major cause of disability in the elderly population. The use of ozone for treatment of knee osteoarthritis (KOA) is controversial and of interest. Although the exact mechanism of ozone for the treatment of KOA is not fully understood, it has been shown that ozone administration may promote oxidative preconditioning or adaptation to oxidative stress, which in turn will result in the stimulation of antioxidant endogenous system which prevents tissue damage. A number of European studies show ozone injection for treatment of KOA results in pain relief, disappearance of edema, and improved mobility. Dosages and volume of injections vary among studies, risk of bias is generally high, and outcomes are inconsistent and not uniformly excellent. At present, there is insufficient evidence to support the effectiveness of ozone therapy for KOA.enKnee osteoarthritisMedical ozone therapyArticleManoto, S. L. (2020). Editorial commentary: Is medical ozone therapy beneficial in the treatment of knee osteoarthritis?. http://hdl.handle.net/10204/11289Manoto, Sello L "Editorial commentary: Is medical ozone therapy beneficial in the treatment of knee osteoarthritis?." (2020) http://hdl.handle.net/10204/11289Manoto SL. Editorial commentary: Is medical ozone therapy beneficial in the treatment of knee osteoarthritis?. 2020; http://hdl.handle.net/10204/11289.TY - Article AU - Manoto, Sello L AB - Osteoarthritis is a degenerative joint disease that is difficult to manage and a major cause of disability in the elderly population. The use of ozone for treatment of knee osteoarthritis (KOA) is controversial and of interest. Although the exact mechanism of ozone for the treatment of KOA is not fully understood, it has been shown that ozone administration may promote oxidative preconditioning or adaptation to oxidative stress, which in turn will result in the stimulation of antioxidant endogenous system which prevents tissue damage. A number of European studies show ozone injection for treatment of KOA results in pain relief, disappearance of edema, and improved mobility. Dosages and volume of injections vary among studies, risk of bias is generally high, and outcomes are inconsistent and not uniformly excellent. At present, there is insufficient evidence to support the effectiveness of ozone therapy for KOA. DA - 2020-01 DB - ResearchSpace DP - CSIR KW - Knee osteoarthritis KW - Medical ozone therapy LK - https://researchspace.csir.co.za PY - 2020 SM - 0749-8063 SM - 1526-3231 T1 - Editorial commentary: Is medical ozone therapy beneficial in the treatment of knee osteoarthritis? TI - Editorial commentary: Is medical ozone therapy beneficial in the treatment of knee osteoarthritis? UR - http://hdl.handle.net/10204/11289 ER -