Siva Mohan Reddy, GJayaramudu, JSadiku, ERRay, Suprakas SVaraprasad, KAderibigbe, BA2014-09-162014-09-162014Siva Mohan Reddy, G, Jayaramudu, J, Sadiku, E.R, Ray, S.S., Varaprasad, K. and Aderibigbe, B.A. 2014. Application of cross-linked soy protein isolate with resorcinol films for release studies of naturally occurring bioactive agent with antiproliferative activity. Journal of Drug Delivery Science and Technology, vol. 24(1), pp 86- 911773-2247http://www.jddst.com/index.php?id_product=1027&controller=producthttp://hdl.handle.net/10204/7673Copyright: 2014 Academy of Pharmaceutical Science and Technology (APST). This is an ABSTRACT ONLY. The definitive version is published in Journal of Drug Delivery Science and Technology, vol. 24(1), pp 86-91The potential of soy protein isolate films as a release system for naturally occurring antiproliferative agent was investigated. The soy protein isolates was cross linked with resorcinol and the resorcinol content was varied between 10-30 %. The release study was monitored over a period of 24 h at a pH of 7.4. Different kinetic release models were used to determine the mechanism of release of bioactive agent from the films. The release profiles of the SPI films of selected degree of cross-linking were anomalous (non-Fickian) and case II transport, with n values in the range of 0.97-1.01. The degree of cross-linking provided an effective means of regulating the release rate of the SPI films, and hence potential for use as drug release system. These films were further characterized by Fourier transform spectroscopy (FTIR), spectroscopy, scanning electron microscope (SEM), X-ray diffraction (XRD) and thermogravimetric analysis (TGA) which confirmed the successful incorporation of curcumin onto the films.enSoy protein isolate filmsCurcuminDrug releaseAnticancerAntibacterialArticleSiva Mohan Reddy, G., Jayaramudu, J., Sadiku, E., Ray, S. S., Varaprasad, K., & Aderibigbe, B. (2014). Application of cross-linked soy protein isolate with resorcinol films for release studies of naturally occurring bioactive agent with antiproliferative activity. http://hdl.handle.net/10204/7673Siva Mohan Reddy, G, J Jayaramudu, ER Sadiku, Suprakas S Ray, K Varaprasad, and BA Aderibigbe "Application of cross-linked soy protein isolate with resorcinol films for release studies of naturally occurring bioactive agent with antiproliferative activity." (2014) http://hdl.handle.net/10204/7673Siva Mohan Reddy G, Jayaramudu J, Sadiku E, Ray SS, Varaprasad K, Aderibigbe B. Application of cross-linked soy protein isolate with resorcinol films for release studies of naturally occurring bioactive agent with antiproliferative activity. 2014; http://hdl.handle.net/10204/7673.TY - Article AU - Siva Mohan Reddy, G AU - Jayaramudu, J AU - Sadiku, ER AU - Ray, Suprakas S AU - Varaprasad, K AU - Aderibigbe, BA AB - The potential of soy protein isolate films as a release system for naturally occurring antiproliferative agent was investigated. The soy protein isolates was cross linked with resorcinol and the resorcinol content was varied between 10-30 %. The release study was monitored over a period of 24 h at a pH of 7.4. Different kinetic release models were used to determine the mechanism of release of bioactive agent from the films. The release profiles of the SPI films of selected degree of cross-linking were anomalous (non-Fickian) and case II transport, with n values in the range of 0.97-1.01. The degree of cross-linking provided an effective means of regulating the release rate of the SPI films, and hence potential for use as drug release system. These films were further characterized by Fourier transform spectroscopy (FTIR), spectroscopy, scanning electron microscope (SEM), X-ray diffraction (XRD) and thermogravimetric analysis (TGA) which confirmed the successful incorporation of curcumin onto the films. DA - 2014 DB - ResearchSpace DP - CSIR KW - Soy protein isolate films KW - Curcumin KW - Drug release KW - Anticancer KW - Antibacterial LK - https://researchspace.csir.co.za PY - 2014 SM - 1773-2247 T1 - Application of cross-linked soy protein isolate with resorcinol films for release studies of naturally occurring bioactive agent with antiproliferative activity TI - Application of cross-linked soy protein isolate with resorcinol films for release studies of naturally occurring bioactive agent with antiproliferative activity UR - http://hdl.handle.net/10204/7673 ER -