Ramjee, GWilliams, BGouws, EVan Dyck, EDe Deken, BKarim, SA2007-03-272007-06-072007-03-272007-06-072005-07-01Ramjee, G, et al. 2005. Impact of incident and prevalent herpes simplex virus-2 infection on the incidence of HIV-1 infection among commercial sex workers in South Africa. Journal of Acquired Immune Deficiency Syndromes, vol. 39(3), pp 333-3391525-4135http://hdl.handle.net/10204/2090http://hdl.handle.net/10204/2090This study investigated the impact of prevalent and incident HSV-2 infection on the incidence of HIV-1 infection in a cohort of female commercial sex workers in KwaZulu-Natal, South Africa. Prior to a vaginal microbicide trial, 416 women were screened for antibodies to HIV-1 and herpes simplex virus-2 (HSV-2) infections and a questionnaire was used to establish behavioural, social, and demographic characteristics. A total of 187 HIV-1-seronegative women were followed up at monthly intervals when blood was drawn and used to detect HIV-1 and HSV-2 antibodies. The median duration of follow-up was 2.2 years. At screening 50% of the women were HIV-1 seropositive and 84% were HSV-2 scropositive. The hazards of HIV-1 among women who were HSV-2 seropositive or seronegative throughout, or among those who seroconverted during the study, were not significantly different. When HSV-2 seroconversion was analyzed as a time-dependent covariate, the hazard ratio for HIV-1 seroconversion was 6.0 (95% Cl: 2.6-14.0) times greater among women with incident than among women with prevalent HSV-2 infections. Drawing on other recent studies these data suggest that incident HSV-2 infection increases the risk of HIV-1 infection; the effect wanes with time since infection; and the effect is significantly greater for men than it is for women.223538 bytesapplication/pdfenCopyright: 2005 Lippincott Williams & WilkinsHerpes simplex virusHuman immunodeficiency virusHIV/AIDSSex workersAcquired immune deficiency syndromeSouth AfricaImmunologyInfectious diseasesArticleRamjee, G., Williams, B., Gouws, E., Van Dyck, E., De Deken, B., & Karim, S. (2005). Impact of incident and prevalent herpes simplex virus-2 infection on the incidence of HIV-1 infection among commercial sex workers in South Africa. http://hdl.handle.net/10204/2090Ramjee, G, B Williams, E Gouws, E Van Dyck, B De Deken, and SA Karim "Impact of incident and prevalent herpes simplex virus-2 infection on the incidence of HIV-1 infection among commercial sex workers in South Africa." (2005) http://hdl.handle.net/10204/2090Ramjee G, Williams B, Gouws E, Van Dyck E, De Deken B, Karim S. Impact of incident and prevalent herpes simplex virus-2 infection on the incidence of HIV-1 infection among commercial sex workers in South Africa. 2005; http://hdl.handle.net/10204/2090.TY - Article AU - Ramjee, G AU - Williams, B AU - Gouws, E AU - Van Dyck, E AU - De Deken, B AU - Karim, SA AB - This study investigated the impact of prevalent and incident HSV-2 infection on the incidence of HIV-1 infection in a cohort of female commercial sex workers in KwaZulu-Natal, South Africa. Prior to a vaginal microbicide trial, 416 women were screened for antibodies to HIV-1 and herpes simplex virus-2 (HSV-2) infections and a questionnaire was used to establish behavioural, social, and demographic characteristics. A total of 187 HIV-1-seronegative women were followed up at monthly intervals when blood was drawn and used to detect HIV-1 and HSV-2 antibodies. The median duration of follow-up was 2.2 years. At screening 50% of the women were HIV-1 seropositive and 84% were HSV-2 scropositive. The hazards of HIV-1 among women who were HSV-2 seropositive or seronegative throughout, or among those who seroconverted during the study, were not significantly different. When HSV-2 seroconversion was analyzed as a time-dependent covariate, the hazard ratio for HIV-1 seroconversion was 6.0 (95% Cl: 2.6-14.0) times greater among women with incident than among women with prevalent HSV-2 infections. Drawing on other recent studies these data suggest that incident HSV-2 infection increases the risk of HIV-1 infection; the effect wanes with time since infection; and the effect is significantly greater for men than it is for women. DA - 2005-07-01 DB - ResearchSpace DP - CSIR KW - Herpes simplex virus KW - Human immunodeficiency virus KW - HIV/AIDS KW - Sex workers KW - Acquired immune deficiency syndrome KW - South Africa KW - Immunology KW - Infectious diseases LK - https://researchspace.csir.co.za PY - 2005 SM - 1525-4135 T1 - Impact of incident and prevalent herpes simplex virus-2 infection on the incidence of HIV-1 infection among commercial sex workers in South Africa TI - Impact of incident and prevalent herpes simplex virus-2 infection on the incidence of HIV-1 infection among commercial sex workers in South Africa UR - http://hdl.handle.net/10204/2090 ER -