Naseria, NAlgana, CJacobs, VJohn, Maya JOksmana, KMathew, AP2014-07-182014-07-182014-08Naseria, N., Algana, C., Jacobs, V., John, M.J., Oksmana, K. and Mathew, A.P. 2014. Electrospun chitosan-based nanocomposite mats reinforced with chitin nanocrystals for wound dressing. Carbohydrate Polymers, vol. 109, pp 7-150144-8617http://ac.els-cdn.com/S014486171400263X/1-s2.0-S014486171400263X-main.pdf?_tid=d54cd224-00fb-11e4-9f64-00000aab0f6b&acdnat=1404204414_df07afd2d0c3a3f961664a8af00c8b22http://hdl.handle.net/10204/7497Copyright: 2014 Elsevier. This is an ABSTRACT ONLY. The definitive version is published in Carbohydrate Polymers, vol. 109, pp 7-15The aim of this study was to develop electrospun chitosan/polyethylene oxide-based randomly oriented fiber mats reinforced with chitin nanocrystals (ChNC) for wound dressing. Microscopy studies showedporous mats of smooth and beadless fibers with diameters between 223 and 966 nm. The addition ofchitin nanocrystals as well as crosslinking had a positive impact on the mechanical properties of the mats, and the crosslinked nanocomposite mats with a tensile strength of 64.9 MPa and modulus of 10.2 GPawere considered the best candidate for wound dressing application. The high surface area of the mats (35 m(sup2)(supg-1) was also considered beneficial for wound healing. The water vapor transmission rate of theprepared mats was between 1290 and 1548 g (supm-2)day(sup-1), and was in the range for injured skin or wounds.The electrospun fiber mats showed compatibility toward adipose derived stem cells, further confirmingtheir potential use as wound dressing materials.enElectrospinningChitinNanocrystalsNanocompositeWound dressingMechanical propertiesCytocompatibilityArticleNaseria, N., Algana, C., Jacobs, V., John, M. J., Oksmana, K., & Mathew, A. (2014). Electrospun chitosan-based nanocomposite mats reinforced with chitin nanocrystals for wound dressing. http://hdl.handle.net/10204/7497Naseria, N, C Algana, V Jacobs, Maya J John, K Oksmana, and AP Mathew "Electrospun chitosan-based nanocomposite mats reinforced with chitin nanocrystals for wound dressing." (2014) http://hdl.handle.net/10204/7497Naseria N, Algana C, Jacobs V, John MJ, Oksmana K, Mathew A. Electrospun chitosan-based nanocomposite mats reinforced with chitin nanocrystals for wound dressing. 2014; http://hdl.handle.net/10204/7497.TY - Article AU - Naseria, N AU - Algana, C AU - Jacobs, V AU - John, Maya J AU - Oksmana, K AU - Mathew, AP AB - The aim of this study was to develop electrospun chitosan/polyethylene oxide-based randomly oriented fiber mats reinforced with chitin nanocrystals (ChNC) for wound dressing. Microscopy studies showedporous mats of smooth and beadless fibers with diameters between 223 and 966 nm. The addition ofchitin nanocrystals as well as crosslinking had a positive impact on the mechanical properties of the mats, and the crosslinked nanocomposite mats with a tensile strength of 64.9 MPa and modulus of 10.2 GPawere considered the best candidate for wound dressing application. The high surface area of the mats (35 m(sup2)(supg-1) was also considered beneficial for wound healing. The water vapor transmission rate of theprepared mats was between 1290 and 1548 g (supm-2)day(sup-1), and was in the range for injured skin or wounds.The electrospun fiber mats showed compatibility toward adipose derived stem cells, further confirmingtheir potential use as wound dressing materials. DA - 2014-08 DB - ResearchSpace DP - CSIR KW - Electrospinning KW - Chitin KW - Nanocrystals KW - Nanocomposite KW - Wound dressing KW - Mechanical properties KW - Cytocompatibility LK - https://researchspace.csir.co.za PY - 2014 SM - 0144-8617 T1 - Electrospun chitosan-based nanocomposite mats reinforced with chitin nanocrystals for wound dressing TI - Electrospun chitosan-based nanocomposite mats reinforced with chitin nanocrystals for wound dressing UR - http://hdl.handle.net/10204/7497 ER -