Adewusi, EAMoodley, NSteenkamp, V2011-03-282011-03-282010-12Adewusi, EA, Moodley, N and Steenkamp, V. 2010. Medicinal plants with cholinesterase inhibitory activity: a review. African Journal of Biotechnology, 9(49), pp 8257-82761684-5315http://www.academicjournals.org/AJB/PDF/pdf2010/6Dec/Adewusi%20et%20al.pdfhttp://hdl.handle.net/10204/4923Copyright: 2010 Academic JournalsAlzheimer’s disease (AD), a common neurodegenerative disease, is characterized by low levels in the brain of the neurotransmitter, acetylcholine (ACh). Clinical treatment of this disease is palliative and relies mostly on enhancing cholinergic function by stimulation of cholinergic receptors or prolonging the availability of ACh released into the neuronal synaptic cleft by use of agents which restore or improve the levels of acetylcholine. Inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), enzymes which breakdown acetylcholine, are considered as a promising strategy for the treatment of AD. A potential source of AChE and BChE inhibitors is provided by the abundance of plants in nature, and natural products continue to provide useful drugs and templates for the development of other compounds. The present work constitutes a review of the literature on 123 species of medicinal plants that have been tested for AChE inhibitory activity and 42 plant species which have been tested for BChE inhibitory activity. The plant species listed are potential cholinesterase inhibitors and may aid researchers in their study of natural products which may be useful in the treatment of AD.enAlzheimer’s diseaseAcetylcholineAcetylcholinesteraseNeurodegenerative diseasesButyrylcholinesteraseMedicinal plantsBiotechnologyMedicinal plants with cholinesterase inhibitory activity: a reviewArticleAdewusi, E., Moodley, N., & Steenkamp, V. (2010). Medicinal plants with cholinesterase inhibitory activity: a review. http://hdl.handle.net/10204/4923Adewusi, EA, N Moodley, and V Steenkamp "Medicinal plants with cholinesterase inhibitory activity: a review." (2010) http://hdl.handle.net/10204/4923Adewusi E, Moodley N, Steenkamp V. Medicinal plants with cholinesterase inhibitory activity: a review. 2010; http://hdl.handle.net/10204/4923.TY - Article AU - Adewusi, EA AU - Moodley, N AU - Steenkamp, V AB - Alzheimer’s disease (AD), a common neurodegenerative disease, is characterized by low levels in the brain of the neurotransmitter, acetylcholine (ACh). Clinical treatment of this disease is palliative and relies mostly on enhancing cholinergic function by stimulation of cholinergic receptors or prolonging the availability of ACh released into the neuronal synaptic cleft by use of agents which restore or improve the levels of acetylcholine. Inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), enzymes which breakdown acetylcholine, are considered as a promising strategy for the treatment of AD. A potential source of AChE and BChE inhibitors is provided by the abundance of plants in nature, and natural products continue to provide useful drugs and templates for the development of other compounds. The present work constitutes a review of the literature on 123 species of medicinal plants that have been tested for AChE inhibitory activity and 42 plant species which have been tested for BChE inhibitory activity. The plant species listed are potential cholinesterase inhibitors and may aid researchers in their study of natural products which may be useful in the treatment of AD. DA - 2010-12 DB - ResearchSpace DP - CSIR KW - Alzheimer’s disease KW - Acetylcholine KW - Acetylcholinesterase KW - Neurodegenerative diseases KW - Butyrylcholinesterase KW - Medicinal plants KW - Biotechnology LK - https://researchspace.csir.co.za PY - 2010 SM - 1684-5315 T1 - Medicinal plants with cholinesterase inhibitory activity: a review TI - Medicinal plants with cholinesterase inhibitory activity: a review UR - http://hdl.handle.net/10204/4923 ER -