Munsamy, SUnderwood, SLabadarios, GRamsundar, Preshen PSha, MBotha, AdeleHerselman, Martha EBotha, AdeleHerselman, Martha ERousseau, P2025-07-212025-07-212024-11978-0-7988-5670-60-7988-5670-Xhttp://hdl.handle.net/10204/14292Purpose: This chapter provides an overview of what constitutes the transformative impact of ePrescribing in enhancing patient care and healthcare efficiency by defining the concept and providing its value chain and ecosystem. It aims to synthesise key findings and insights to offer meaningful suggestions further to form the groundwork for a National South African Implementation. Study design/methodology/approach: This chapter applied a qualitative exploratory approach to study relevant literature on the phenomena of ePrescribing. Using this method, one can map the existing knowledge of the phenomena and identify gaps the studies address. Document and thematic analysis were used to examine and interpret data from the selected articles to uncover meaning, gain understanding, and conclude. Understanding this concept's challenges, building blocks, design elements, and realities will add to its applicability within an African context. Originality/value: By leveraging digital technology, ePrescribing systems can give clinicians real-time access to patient medication histories, drug interactions, and formulary information, enabling them to make more informed and safer prescribing decisions. It conceptualises ePrescription, highlighting possible challenges and opportunities within the emerging South African Health Information system. Findings: Electronic prescribing, or ePrescribing, has gained significant traction in recent years, potentially improving the efficiency and accuracy of the prescribing process in ambulatory care settings.FulltextenePrescribingePrescriptionNational South African Health ImplementationBook Chaptern/a